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GPR78 belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene.
|Gene Name:||G protein-coupled receptor 78|
|Family/Subfamily:||GPCR , Orphan-U|
|Synonyms:||GPR78, G protein-coupled receptor 78, G-protein coupled receptor 78|
|Target Sequences:||NM_080819 NP_543009.2 Q96P69|
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