GRIA2 / GLUR2

glutamate receptor, ionotropic, AMPA 2

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

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Proteins (3)

Type

Over-Expression Lysate (2)

Synthetic Peptide (1)

Target

GRIA2 / GLUR2 (3)

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No (3)

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Myc-DDK (Flag) (2)

Species

Human (2)

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293T Cells (1)

HEK 293 Cells (1)

Synthetic (1)

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Purified (1)

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Human GRIA2 / GLUR2 Protein (Synthetic Peptide) - LS-G37580

Source:

Synthetic

Tag:

None

Price:

50 µg/$313

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Human GRIA2 / GLUR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76173

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.6 kDa

Price:

20 µg/$215

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GRIA2 / GLUR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119829

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.6 kDa

Price:

100 µg/$710

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