GRIN2B / NMDAR2B / NR2B

glutamate receptor, ionotropic, N-methyl D-aspartate 2B

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged; memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity.

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Products

Proteins (6)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (2)

Target

GRIN2B / NMDAR2B / NR2B (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His, N-Terminal (2)

His-GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (1)

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Human GRIN2B / NMDAR2B / NR2B Protein (Recombinant His-GST, N-terminus) (aa35-557) - LS-G25529

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

89 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human GRIN2B / NMDAR2B / NR2B Protein (Recombinant GST, N-terminus) (aa127-236) - LS-G58757

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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GRIN2B / NMDAR2B / NR2B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122970

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

166.37 kDa

Price:

100 µg/$710

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Human GRIN2B / NMDAR2B / NR2B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81443

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

166.37 kDa

Price:

20 µg/$215

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Human GRIN2B / NMDAR2B / NR2B Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Arg27-Asp557) - LS-G136107

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~84 kDa

Price:

200 µl/$283

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Human GRIN2B / NMDAR2B / NR2B Protein (Over-Expression Lysate His, N-Terminal) (Arg27-Asp557) - LS-G136108

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~84 kDa

Price:

100 µg/$298

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