H2AFX / H2AX

H2A histone family, member X

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

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Products

ELISA Kits (8)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Development Kit (1)

Sandwich (4)

Sandwich CLIA (1)

Target

H2AFX / H2AX (8)

Reactivity

Human (6)

Mouse (4)

Rat (2)

Product Group

DevKit DuoPlus (1)

Format

96-Well Microplate (2)

96-Well Strip Plate (4)

Antibody Pair and Standard (1)

Publications

No (8)

Sample Type

Adherent Cell Cultures (2)

Cell Culture Supernatants (3)

Cell Lysates (4)

Plasma (2)

Serum (2)

Tissue Homogenates (4)

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Mouse/Human/Rat Phospho-H2AFX / H2AX (Ser139) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1529

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human H2AFX / H2AX (Sandwich ELISA) ELISA Kit - LS-F17627

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse H2AFX / H2AX (Sandwich ELISA) ELISA Kit - LS-F17626

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Human H2AFX / H2AX (Sandwich ELISA) ELISA Kit - LS-F25619

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$792

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Mouse/Human/Rat H2AFX / H2AX (Cell-Based ELISA) ELISA Kit - LS-F2050

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse H2AFX / H2AX (Sandwich ELISA) ELISA Kit - LS-F33081

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates

Price:

1 Plate/$579

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Human H2AFX / H2AX (CLIA) ELISA Kit - LS-F74620

Type:

Sandwich CLIA

Reactivity:

Human

Range:

27.4 - 20000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$785

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DevKit DuoPlus Human H2AFX / H2AX ELISA Development Kit - LS-F72259

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,370; 1000 Wells/$2,059

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