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HAMP / Hepcidin
hepcidin antimicrobial peptide
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).
| Gene Name: | hepcidin antimicrobial peptide |
| Synonyms: | HAMP, Hepcidin antimicrobial peptide, LEAP-1, LEAP1, HEPC, Hepcidin, HFE2B, PLTR, Putative liver tumor regressor |
| Target Sequences: | NM_021175 NP_066998.1 P81172 |
Publications (6)
1
Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss. Hao-Han Guo , Lei Xiong , Jin-Xiu Pan, Daehoon Lee, Kevin Liu, Xiao Ren, Bo Wang, Xiao Yang, Shun Cui, Lin Mei, Wen-Cheng Xiong. Bone research. 2021 June;9:31. [Full Text Article]
[PubMed:34108442]
[PMC:PMC8190093]
2
Low Serum Hepcidin Is Associated With Reduced Short-Term Survival in Adults With Acute Liver Failure. Igor Spivak, Jyoti Arora, Caitlyn Meinzer, Valerie Durkalski-Mauldin, William M Lee, Christian Trautwein, Robert J Fontana, Pavel Strnad, Acute Liver Failure Study Group (ALFSG). Hepatology (Baltimore, Md.). 2019 May;69:2136-2149. [Full Text Article]
[PubMed:30582749]
3
Development of a model for anemia of inflammation that is relevant to critical care. Margit Boshuizen, Robin van Bruggen, Sebastian A Zaat, Marcus J Schultz, Eli Aguilera, Ana Motos, Tarek Senussi, Francesco Antonio Idone, Paolo Pelosi, Antonio Torres, Gianluigi Li Bassi, Nicole P Juffermans. Intensive care medicine experimental. 2019 July;7:47. [Full Text Article]
[PubMed:31346819]
[PMC:PMC6658638]
☰ Filters
Products
Proteins
(13)
Type
Over-Expression Lysate
(2)
Recombinant
(11)
Target
HAMP / Hepcidin
(13)
Publications
No
(13)
Tag
GST
(1)
GST, N-terminus
(2)
His, N-Terminal
(2)
His, N-terminus + Human IgG Fc, C-terminus
(1)
His-GST
(3)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Human
(7)
Large Yellow Croaker
(1)
Mouse
(1)
Pig
(1)
Rat
(1)
Source
293T Cells
(1)
E. coli
(8)
HEK 293 Cells
(2)
Human
(1)
Wheat Germ Extract
(1)
Purification
Purified
(4)
Low Endotoxin Level
Low endotoxin level
(2)
Human
His, N-terminus + Human IgG Fc, C-terminus
34.1kDa
50 µg/$722; 10 µg/$326; 200 µg/$1,325; 1 mg/$2,597; 5 mg/$5,041; 2 mg/$2,788
E. coli
His, N-Terminal
12.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His, N-Terminal
12.6 kDa
10 µg/$274; 50 µg/$400; 100 µg/$637; 200 µg/$797; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053
HEK 293 Cells
Myc-DDK (Flag)
6.9 kDa
20 µg/$1,107
E. coli
His-GST
38.7 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
E. coli
His-GST
33.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His-GST
36.0 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
Wheat Germ Extract
GST
32.34 kDa
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
6.9 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
6.9 kDa
100 µg/$494
E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.2 kDa
10 µg/$344; 50 µg/$584
E. coli
None
1 mg/$1,568; 100 µg/$534; 20 µg/$422
E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.2kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
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