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Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Gene Name: | HMG-box transcription factor 1 |
Synonyms: | HBP1, HMG box-containing protein 1, HMG box transcription factor 1, HMG-box transcription factor 1, USMCC2 |
Target Sequences: | NM_012257 NP_036389.2 O60381 |
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