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HDAC4

histone deacetylase 4

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Gene Name: histone deacetylase 4
Family/Subfamily: Histone Deacetylase , not assigned-Histone Deacetylase
Synonyms: HDAC4, BDMR, AHO3, Histone deacetylase A, HD4, HA6116, HDAC-A, HDACA, Histone deacetylase 4, HDAC-4, KIAA0288
Target Sequences: NM_006037 NP_006028.2 P56524

Publications (2)

1
The Role of Zinc on Liver Fibrosis by Modulating ZIP14 Expression Throughout Epigenetic Regulatory Mechanisms. Zeynep Busra Aksoy-Ozer, Ceylan Verda Bitirim, Belma Turan, Kamil Can Akcali. Biological trace element research. 2024 January; [Full Text Article] [PubMed:38221603]
2
Inhibition of histone deacetylase 4 increases cytotoxicity of docetaxel in gastric cancer cells. Colarossi L, Memeo L, Colarossi C, Aiello E, Iuppa A, Espina V, Liotta L, Mueller C. Proteomics. Clinical applications. Dec;8:924-31. [Full Text Article] [PubMed:25091122] Related Antibodies: LS-B2033.

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HDAC4 Antibody - Anti-HDAC4 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HDAC4 Rabbit anti-Human Polyclonal (aa194-209) Antibody
Mouse, Human
ChrIP, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
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HDAC4 Mouse anti-Human Monoclonal (7E2E6) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
HDAC4 Antibody - Anti-HDAC4 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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HDAC4 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
HDAC4 Antibody - Western blot of Phospho-HDAC4 (S632) antibody
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HDAC4 Rabbit anti-Human Polyclonal (570-650 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HDAC4 Antibody - The lack of description.
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HDAC4 Mouse anti-Human Monoclonal (N-Terminus) Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
HDAC4 Antibody - Immunohistochemistry (IHC) analysis of HDAC4 pAb in paraffin-embedded H-lung tissue.
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HDAC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$356; 100 µl/$461
HDAC4 Antibody - Anti-HDAC4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HDAC4 Mouse anti-Human Monoclonal (2B11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HDAC4 Antibody - HDAC4 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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HDAC4 Rabbit anti-Human Polyclonal (aa1049-1077) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
HDAC4 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HDAC4 Rabbit anti-Human Polyclonal (aa1052-1084) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
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HDAC4 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IP, WB
Unconjugated
100 µl/$412
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HDAC4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
HDAC4 Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using HDAC4 Polyclonal Antibody at dilution of 1:100 (40x lens).
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HDAC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
HDAC4 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HDAC4 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
HDAC4 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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HDAC4 Rabbit anti-Human Polyclonal (pSer632) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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HDAC4 Rabbit anti-Human Polyclonal (aa1049-1077) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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HDAC4 Rabbit anti-Human Polyclonal (aa1049-1077) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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HDAC4 Rabbit anti-Human Polyclonal (aa1049-1077) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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HDAC4 Rabbit anti-Human Polyclonal (aa1049-1077) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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HDAC4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
HDAC4 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using HDAC4 Antibody at dilution of 1:20
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HDAC4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
HDAC4 Antibody - Immunohistochemistry of paraffin-embedded human mammary cancer tissue.
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HDAC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
HDAC4 Antibody - Immunohistochemistry of paraffin-embedded human stomach using HDAC4 antibody at dilution of 1:100 (40x lens).
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HDAC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
HDAC4 Antibody - HDAC4 Antibody in Western Blot (WB)
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HDAC4 Mouse anti-Human Monoclonal (7B2) Antibody
Mouse, Human
ChIP-Seq, WB
Unconjugated
100 µl/$541
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HDAC4 Mouse anti-Human Monoclonal (5E4A5) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
HDAC4 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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HDAC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).