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HES1 / HES-1
hes family bHLH transcription factor 1
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
| Gene Name: | hes family bHLH transcription factor 1 |
| Synonyms: | HES1, BHLHb39, HHL, HL, Hairy and enhancer of split 1, Hairy homolog, HRY, Hairy homolog (Drosophila), Transcription factor HES-1, Hairy-like protein, HES-1 |
| Target Sequences: | NM_005524 NP_005515.1 Q14469 |
Publications (2)
1
Integrated Immunohistochemical Study on Small-Cell Carcinoma of the Lung Focusing on Transcription and Co-Transcription Factors. Younosuke Sato, Isamu Okamoto, Hiroki Kameyama, Shinji Kudoh, Haruki Saito, Mune Sanada, Noritaka Kudo, Joeji Wakimoto, Kosuke Fujino, Yuki Ikematsu, Kentaro Tanaka, Ayako Nishikawa, Ryo Sakaguchi, Takaaki Ito. Diagnostics (Basel, Switzerland). 2020 November;10: [Full Text Article]
[PubMed:33202998]
[PMC:PMC7697657]
Related Antibodies: LS-C337570.
2
The novel anti-colitic effect of ß-adrenergic receptors via modulation of PS1/BACE-1/Aß axis and NOTCH signaling in an ulcerative colitis model. Salma Nasser, Dalaal M Abdallah, Kawkab A Ahmed, Yousra Abdel-Mottaleb, Hanan S El-Abhar. Frontiers in pharmacology. 2022 November;13:1008085. [Full Text Article]
[PubMed:36386153]
[PMC:PMC9641009]
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Type
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(69)
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(7)
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(5)
Target
HES1 / HES-1
(86)
Reactivity
Human
(63)
Mouse
(34)
Rat
(19)
Bat
(4)
Bovine
(7)
Chicken
(1)
Chimpanzee
(3)
Gibbon
(3)
Guinea pig
(3)
Hamster
(1)
Horse
(4)
Monkey
(6)
Pig
(6)
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(4)
Rodent
(5)
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(4)
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(4)
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(19)
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(1)
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(6)
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(68)
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(5)
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(13)
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(1)
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(14)
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(4)
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rabbit
(49)
mouse
(18)
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(1)
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(1)
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(2)
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(1)
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(29)
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(13)
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(1)
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(1)
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(2)
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(1)
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monoclonal mc
(19)
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(50)
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(8)
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(6)
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(6)
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(6)
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(4)
Unconjugated
(41)
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aa21-251
(8)
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aa3-32
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aa22-71
(4)
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aa102-137
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aa205-239
(1)
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(1)
aa259-293
(1)
aa3-16
(1)
aa36-143
(1)
aa9-38
(1)
Publications
No
(84)
Yes
(2)
Sample Type
Plasma
(5)
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(5)
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(2)
Tag
GST
(1)
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(2)
His
(1)
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(1)
His-T7
(1)
Myc-DDK (Flag)
(3)
Species
Human
(8)
Source
293T Cells
(1)
E. coli
(3)
HEK 293 Cells
(2)
Wheat Germ Extract
(3)
Purification
Purified
(2)
HES1 / HES-1 Rabbit anti-Human Polyclonal (aa24-35) Antibody
Xenopus, Zebrafish, Horse, Rat, Hamster, Rabbit, Mouse, Bovine, Bat, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$485
HES1 / HES-1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rodent, Human
IF, IHC, WB
Biotin Conjugated
100 µl/$1,094
HES1 / HES-1 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Rodent, Human
IF, IHC, WB
FITC Conjugated
100 µl/$1,094
HES1 / HES-1 Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Rodent, Human
IF, IHC, WB
APC Conjugated
100 µl/$1,094
HES1 / HES-1 Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Rodent, Human
IF, IHC, WB
PE Conjugated
100 µl/$1,094
HES1 / HES-1 Mouse anti-Human Monoclonal (OTI2D2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$450
HES1 / HES-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2D2) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HES1 / HES-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
HES1 / HES-1 Rat anti-Rat Monoclonal (NM1) Antibody
Mouse, Rat
ICC, IP, WB
Unconjugated
100 µg/$436
HES1 / HES-1 Mouse anti-Human Monoclonal (OTI7B9) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Neuroscience
HES1 / HES-1 Mouse anti-Human Monoclonal (OTI1B5) Antibody
Human
IF, IHC-P, WB
Unconjugated
50 µl/$460
HES1 / HES-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1B5) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HES1 / HES-1 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
WB
Unconjugated
100 µl/$424
HES1 / HES-1 Rabbit anti-Human Polyclonal (aa3-32) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
HES1 / HES-1 Rabbit anti-Human Polyclonal (aa22-71) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$397
HES1 / HES-1 Mouse anti-Human Monoclonal (aa1-280) (Carrier-free) (OTI4H1) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HES1 / HES-1 Mouse anti-Human Monoclonal (OTI1H8) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
HES1 / HES-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1H8) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
HES1 / HES-1 Rabbit anti-Human Polyclonal (aa9-38) Antibody
Human
Flo, IF, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
HES1 / HES-1 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
HES1 / HES-1 Mouse anti-Human Monoclonal (C-Terminus) (7C2g2) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$468
HES1 / HES-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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