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HLA-DRA

Major Histocompatibility Complex, class II, DR alpha

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

Gene Name: Major Histocompatibility Complex, class II, DR alpha
Synonyms: HLA-DRA, HLA-DRA1, MHC cell surface glycoprotein, MHC class II antigen DRA, MLRW
Target Sequences: NM_019111 NP_061984.2 P01903

Publications (2)

1
Assessment of the genetic basis of rosacea by genome-wide association study. Chang ALS, Raber I, Xu J, Li R, Spitale R, Chen J, Kiefer AK, Tian C, Eriksson NK, Hinds DA, Tung JY. The Journal of investigative dermatology. 2015 135:1548-1555. (IHC; Human) [Full Text Article] [PubMed:25695682] [PMC:PMC4434179]
2
Secukinumab, a novel anti-IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity. Karle A, Spindeldreher S, Kolbinger F. mAbs. 2016 8:536-50. (WB; Human) [Full Text Article] [PubMed:26817498] [PMC:PMC4966846]

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Proteins (12)
Over-Expression Lysate (1)
Recombinant (11)
HLA-DRA (12)
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6His, N-terminus (2)
His (8)
His, N-Terminal (1)
Myc-DDK (Flag) (1)
Bovine (1)
Dog (1)
Human (7)
Pig (1)
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Rhesus monkey (1)
293T Cells (1)
E. coli (10)
Yeast (1)
Purified (3)
HLA-DRA Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
HLA-DRA Protein
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E. coli
His, N-Terminal
28 kDa
10 µg/$265; 100 µg/$365; 200 µg/$484; 50 µg/$315
HLA-DRA Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
HLA-DRA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26 kDa
20 µg/$150
HLA-DRA Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
30.0 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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E. coli
His
29.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HLA-DRA Protein - Recombinant Major Histocompatibility Complex Class II DR Alpha By SDS-PAGE
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E. coli
His
23.4 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
HLA-DRA Protein - Recombinant Major Histocompatibility Complex Class II DR Alpha By SDS-PAGE
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E. coli
His
23.6 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
HLA-DRA Protein - Recombinant Major Histocompatibility Complex Class II DR Alpha By SDS-PAGE
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E. coli
His
23.5 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
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E. coli
His
23.5 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
HLA-DRA Protein - Recombinant Major Histocompatibility Complex Class II DR Alpha By SDS-PAGE
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E. coli
His
23.8 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
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E. coli
His
24.6 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).