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HLA-G

Major Histocompatibility Complex, Class I, G Heavy Chain

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

Gene Name: Major Histocompatibility Complex, Class I, G Heavy Chain
Synonyms: HLA-G, HLAG, HLA-6.0, MHC class I antigen G, HLA G antigen
Target Sequences: NM_002127 NP_002118.1 P17693

Publications (5)

1
HLA-G expression is an independent predictor for improved survival in high grade ovarian carcinomas. Rutten MJ, Dijk F, Savci-Heijink CD, Buist MR, Kenter GG, van de Vijver MJ, Jordanova ES. Journal of immunology research. 2014 2014:274584. (ICC; Human) [Full Text Article] [PubMed:24987709] [PMC:PMC4058481]
2
HLA-G expression and role in advanced-stage classical Hodgkin lymphoma. Caocci G, Greco M, Fanni D, Senes G, Littera R, Lai S, Risso P, Carcassi C, Faa G, La Nasa G. European journal of histochemistry : EJH. 2016 60:2606. (ICC; Human) [Full Text Article] [PubMed:27349312] [PMC:PMC4933823]
3
Study of immune-tolerized cell lines and extracellular vesicles inductive environment promoting continuous expression and secretion of HLA-G from semiallograft immune tolerance during pregnancy. Kyoungshik Cho, Hyejin Kook, Suman Kang, Jangho Lee. Journal of Extracellular Vesicles. 2020 July;9:1795364. [Full Text Article] [PubMed:32944184] [PMC:PMC7480490]
4
Prostaglandin E2 Receptor 4 (EP4) Affects Trophoblast Functions via Activating the cAMP-PKA-pCREB Signaling Pathway at the Maternal-Fetal Interface in Unexplained Recurrent Miscarriage. Lin Peng , Anca Chelariu-Raicu, Yao Ye, Zhi Ma, Huixia Yang, Hellen Ishikawa-Ankerhold, Martina Rahmeh, Sven Mahner, Udo Jeschke , Viktoria von Schönfeldt. International journal of molecular sciences. 2021 Aug;22:9134. [Full Text Article] [PubMed:34502044] [PMC:PMC8430623] Related Antibodies: LS-C204117.
5
The double-sided of human leukocyte antigen-G molecules in type 1 autoimmune hepatitis. Roberto Littera, Andrea Perra, Michela Miglianti, Ignazio S Piras, Stefano Mocci, Sara Lai, Maurizio Melis, Teresa Zolfino, Cinzia Balestrieri, Maria Conti, Giancarlo Serra, Francesco Figorilli, Davide Firinu, Simona Onali, Laura Matta, Carmen Porcu, Francesco Pes, Daniela Fanni, Cristina Manieli, Monica Vacca, Roberto Cusano, Marcello Trucas, Selene Cipri, Stefania Tranquilli, Stefania Rassu, Federica Cannas, Mauro Giovanni Carta, Marta Anna Kowalik, Erika Giuressi, Gavino Faa, Luchino Chessa,. Frontiers in immunology. 2022 November;13:1007647. [Full Text Article] [PubMed:36311782] [PMC:PMC9597675]
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Antibodies (101)
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HLA-G (101)
Human (101)
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rabbit (29)
mouse (72)
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HLA-G Antibody - Anti-HLA-G antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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HLA-G Rabbit anti-Human Polyclonal (aa45-94) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
HLA-G Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HLA-G Mouse anti-Human Monoclonal (C-Terminus) (2A12) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$347
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HLA-G Mouse anti-Human Monoclonal (Biotin) (MEM-G/9) Antibody
Human
ELISA, Flo, IHC, IHC-Fr
Biotin Conjugated
100 µg/$982
HLA-G Antibody - Analysis of cytolytical activity of human polyclonal NK cells on target melanoma cells. Blocking of HLA-G1 on transfectants with anti-human HLA-G (87G) restored specific lysis.  Target cells: M8 cell line transfected with empty vector (column 1) and with HLA-G1 cDNA (columns 2-6).  Blocking antibodies:  Column 1-2: none  Column 3: Isotype mouse IgG2a control  Column 4: anti-human HLA-G (87G) purified  Column 5: anti-human HLA-G (87G) F(ab´)2 fragment  Column 6: anti-human HLA-G (MEM-G/9)
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HLA-G Mouse anti-Human Monoclonal (87G) Antibody
Human
ELISA, Flo, IHC-Fr
Unconjugated
0.1 mg/$347
HLA-G Antibody - Western Blotting analysis of whole cell lysate of HLA-G stable transfectants (various splice variants) using anti-human HLA-G (5A6G7).  Lane 1: M8 cell line transfected with empty vector  Lane 2: M8 cell line transfected with HLA-G1  Lane 3: M8 cell line transfected with HLA-G5  Lane 4: M8 cell line transfected with HLA-G6
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HLA-G Mouse anti-Human Monoclonal (C-Terminus) (5A6G7) Antibody
Human
ELISA, Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$347
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HLA-G Mouse anti-Human Monoclonal (Concentrated) (Biotin) (MEM-G/9) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IP
Biotin Conjugated, Concentrated
0.1 mg/$840
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HLA-G Mouse anti-Human Monoclonal (Concentrated) (MEM-G/9) Antibody
Human
ELISA, Flo, IHC, IHC-Fr
Unconjugated, Concentrated
0.1 mg/$571
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HLA-G Mouse anti-Human Monoclonal (Azide-free) (MEM-G/9) Antibody
Human
ELISA, Flo, ICC, IHC, IHC-Fr, IP
Unconjugated, Azide-free
0.1 mg/$347
HLA-G Antibody - Double surface staining of HLA-G1 transfectants (viable cells gate) using anti-human HLA-G (MEM-G/9) APC and anti-human HLA-G (MEM-G/11) FITC .
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HLA-G Mouse anti-Human Monoclonal (APC) (MEM-G/9) Antibody
Human
ELISA, Flo, ICC, IHC-Fr, IP
APC Conjugated
0.1 mg/$467
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HLA-G Mouse anti-Human Monoclonal (FITC) (MEM-G/9) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$432
HLA-G Antibody - Western blot analysis of extracts of human placenta.
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HLA-G Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
HLA-G Antibody - Immunohistochemistry staining with anti-human HLA-G (MEM-G/1) - pulmonary disseases (paraffin-embedded sections). The antibody MEM-G/1 stains infiltrating macrophages in pulmonary diseases. In the top left corner see the detail of macrophage.
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HLA-G Mouse anti-Human Monoclonal (MEM-G/1) Antibody
Human
IHC, IHC-Fr, WB
Unconjugated
0.1 mg/$347
HLA-G Antibody - Western blotting analysis (reducing conditions) of HLA-G1 in HLA-G1 transfectants using the antibody MEM-G/1 biotin.
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HLA-G Mouse anti-Human Monoclonal (Biotin) (MEM-G/1) Antibody
Human
IHC-Fr, IHC-P, WB
Biotin Conjugated
0.1 mg/$419
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HLA-G Rabbit anti-Human Polyclonal (aa62-89) (Biotin) Antibody
Human
Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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HLA-G Rabbit anti-Human Polyclonal (aa62-89) (FITC) Antibody
Human
Flo, IHC, WB
FITC Conjugated
200 µl/$952
HLA-G Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using HLA-G Antibody at dilution of 1:50
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HLA-G Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
HLA-G Antibody - Immunoprecipitation of HLA-G from HLA-G1 transfectants (LCL-HLA-G1) by anti-human HLA-G (MEM-G/9) and protein G. HLA-G was detected by anti-human HLA-G (4H84) and goat anti-mouse HRP in cell lysate (Lane 1) and in the immunoprecipitate (Lane 2).
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HLA-G Mouse anti-Human Monoclonal (MEM-G/9) Antibody
Human
ELISA, Flo, ICC, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$347
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HLA-G Mouse anti-Human Monoclonal (MEM-G/9) Antibody
Human
ELISA, Flo, IF, IHC-Fr
Unconjugated
0.2 mg/$545
HLA-G Antibody - HLA-G (soluble) Antibody in Western Blot (WB)
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HLA-G Mouse anti-Human Monoclonal (5A6G7) Antibody
Human
ELISA, Flo, ICC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$423
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HLA-G Mouse anti-Human Monoclonal (MEM-G/11) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$347
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HLA-G Mouse anti-Human Monoclonal (MEM-G/9) Antibody
Human
ELISA, Flo, IHC, IHC-Fr
Unconjugated
200 µg/$810
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HLA-G Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, Flo, IF, IHC
HRP Conjugated
100 µl/$1,035
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HLA-G Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, Flo, IF, IHC
Biotin Conjugated
100 µl/$1,035
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HLA-G Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, Flo, IF, IHC
PE Conjugated
100 µl/$1,035
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HLA-G Mouse anti-Human Monoclonal (MEM-G/9) Antibody
Human
ELISA, Flo, IHC, IHC-Fr
Unconjugated
100 µg/$742
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).