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HRH1 / Histamine H1 Receptor

histamine receptor H1

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: histamine receptor H1
Family/Subfamily: GPCR , Histamine
Synonyms: HRH1, H1 histamine receptor, H1 receptor, Histamine 1 receptor, Histamine H1 receptor, H1-R, H1R, Histamine H(1) receptor, Histamine receptor H1, HisH1
Target Sequences: NM_000861 NP_000852.1 P35367

Publications (4)

1
A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells. Uchida H, Machida M, Miura T, Kawasaki T, Okazaki T, Sasaki K, Sakamoto S, Ohuchi N, Kasahara M, Umezawa A, Akutsu H. JCI insight. 2017 2:e86492. (ICC; Human) [Full Text Article] [PubMed:28097227] [PMC:PMC5214546] Related Antibodies: LS-B1745.
2
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Hongzhong Li, Yi Xiao, Qin Li, Jun Yao, Xiangliang Yuan, Yuan Zhang, Xuedong Yin, Yohei Saito, Huihui Fan, Ping Li, Wen-Ling Kuo, Angela Halpin, Don L Gibbons, Hideo Yagita, Zhongming Zhao, Da Pang, Guosheng Ren, Cassian Yee, J Jack Lee, Dihua Yu. Cancer cell. 2022 January;40:36-52.e9. [Full Text Article] [PubMed:34822775] [PMC:PMC8779329] Related Antibodies: LS-C331459.
3
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans. Jonathon L McClain, Elvio A Mazzotta, Nidia Maradiaga, Natalia Duque-Wilckens, Iveta Grants, Alfred J Robison, Fievos L Christofi, Adam J Moeser, Brian D Gulbransen. American journal of physiology. Gastrointestinal and liver physiology. 2020 December;319:G655-G668. [Full Text Article] [PubMed:32996781] [PMC:PMC7792668] Related Antibodies: LS-B1745.
4
Estrogenic regulation of histamine receptor subtype H1 expression in the ventromedial nucleus of the hypothalamus in female rats. Mori H, Matsuda K, Yamawaki M, Kawata M. PloS one. 2014 9:e96232. [Full Text Article] [PubMed:24805361] [PMC:PMC4013143] Related Antibodies: LS-B1745.
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ELISA Kits (4)
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HRH1 / Histamine H1 Receptor (4)
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HRH1 / Histamine H1 Receptor ELISA Kit
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Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
HRH1 / Histamine H1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
HRH1 / Histamine H1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HRH1 / Histamine H1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$783
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).