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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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HTR6 / 5-HT6 Receptor
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
5-HT6, a Serotonin Receptor, appears to regulate cholinergic neurotransmission in the brain rather than the expected interaction as a modulator of dopaminergic transmission. This interaction predicts a possible role for 5-HT6 Receptor antagonists in the treatment of learning and memory disorders. The 5-HT6 Receptor is abundant in limbic areas, which participate in the control of mood and emotion. Some antidepressants and antipsychotics are potent 5-HT6 Receptor antagonists, making this gene valuable for the pharmaceutical industry. 5-HT6 may be involved in the pathogenesis of mood disorders, schizophrenia, in Alzheimer's disease. A splice variant that has a 289bp deletion in the transmembrane region IV and the third intracellular loop has been isolated.
| Gene Name: | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled |
| Family/Subfamily: | GPCR , Serotonin |
| Synonyms: | HTR6, 5-HT6, 5-HT6R, 5-HT-6, 5-hydroxytryptamine receptor 6, 5-HT6 receptor, 5-HT6 serotonin receptor, 5-hydroxytryptamine 6 receptor, Serotonin 6 receptor, Serotonin receptor 6, Serotonin 5-HT-6 receptor, Serotonin type 6 receptor, Histamine receptor H6 |
| Target Sequences: | NM_000871 NP_000862.1 P50406 |
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