HTRA1

HtrA serine peptidase 1

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

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Products

ELISA Kits (12)

Type

Custom (1)

Sandwich (9)

Sandwich CLIA (2)

Target

HTRA1 (12)

Reactivity

Human (6)

Mouse (1)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (10)

Publications

No (11)

Yes (1)

Sample Type

Plasma (7)

Serum (7)

Tissue Homogenates (1)

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Human HTRA1 (Sandwich ELISA) ELISA Kit - LS-F11673

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human HTRA1 (Sandwich ELISA) ELISA Kit - LS-F6692

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$792

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Human HTRA1 (CLIA) ELISA Kit - LS-F26361

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

8.23 - 6000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$851

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Human HTRA1 (Sandwich ELISA) ELISA Kit - LS-F21937

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Monkey HTRA1 (Sandwich ELISA) ELISA Kit - LS-F44887

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse HTRA1 (Custom ELISA) ELISA Kit - LS-F19017

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human HTRA1 (Sandwich ELISA) ELISA Kit - LS-F35807

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human HTRA1 (CLIA) ELISA Kit - LS-F29377

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Chicken HTRA1 (Sandwich ELISA) ELISA Kit - LS-F44888

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Porcine HTRA1 (Sandwich ELISA) ELISA Kit - LS-F44889

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Rabbit HTRA1 (Sandwich ELISA) ELISA Kit - LS-F44890

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Sheep HTRA1 (Sandwich ELISA) ELISA Kit - LS-F44891

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$691

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