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HTRA1

HtrA serine peptidase 1

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Gene Name: HtrA serine peptidase 1
Family/Subfamily: Protease , Serine S1C
Synonyms: HTRA1, ARMD7, HtrA serine peptidase 1, IGFBP5-protease, HtrA, ORF480, Serine protease 11, CARASIL, L56, PRSS11, Serine protease HTRA1
Target Sequences: NM_002775 NP_002766.1 Q92743

Publications (2)

1
Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. Chamberland A, Wang E, Jones AR, Collins-Racie LA, LaVallie ER, Huang Y, Liu L, Morris EA, Flannery CR, Yang Z. The Journal of biological chemistry. 2009 284:27352-9. [PubMed:19657146] [PMC:PMC2785663] Related Antibodies: LS-C98879.
2
The Serine Protease HTRA-1 Is a Biomarker for ROP and Mediates Retinal Neovascularization. Leah A Owen, Kinsey Shirer, Samuel A Collazo, Kathryn Szczotka, Shawna Baker, Blair Wood, Lara Carroll, Benjamin Haaland, Takeshi Iwata, Lakshmi D Katikaneni, Margaret M DeAngelis. Frontiers in molecular neuroscience. 2020 December;13:605918. [Full Text Article] [PubMed:33281553] [PMC:PMC7705345]

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Proteins (10)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (6)
HTRA1 (10)
No (10)
6His, N-terminus (2)
6His-SUMO, N-terminus (1)
His (2)
His-GST (1)
Myc-DDK (Flag) (3)
Myc-DDK (Flag), C-terminus (1)
E. coli (2)
Human (5)
Mouse (2)
293T Cells (1)
E. coli (4)
HEK 293 Cells (5)
Purified (1)
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HEK 293 Cells
6His, N-terminus
49 kDa
100 µg/$298
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HEK 293 Cells
6His, N-terminus
49 kDa
200 µl/$283
HTRA1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HTRA1 Protein - Recombinant HtrA Serine Peptidase 1 By SDS-PAGE
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E. coli
His-GST
49.1 kDa
10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453
HTRA1 Protein - Purified recombinant protein HTRA1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
49 kDa
20 µg/$1,107
HTRA1 Protein - Recombinant HtrA Serine Peptidase 1 By SDS-PAGE
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E. coli
His
15.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
HTRA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
51.53 kDa
20 µg/$215
HTRA1 Protein - Recombinant HtrA Serine Peptidase 1 By SDS-PAGE
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E. coli
His
15.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
HTRA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
51.53 kDa
100 µg/$710
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HEK 293 Cells
Myc-DDK (Flag), C-terminus
49 kDa
20 µg/$1,107
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).