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Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Gene Name: | HtrA serine peptidase 1 |
Family/Subfamily: | Protease , Serine S1C |
Synonyms: | HTRA1, ARMD7, HtrA serine peptidase 1, IGFBP5-protease, HtrA, ORF480, Serine protease 11, CARASIL, L56, PRSS11, Serine protease HTRA1 |
Target Sequences: | NM_002775 NP_002766.1 Q92743 |
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