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ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Gene Name: | intercellular adhesion molecule 1 |
Family/Subfamily: | ICAM , not assigned-ICAM |
Synonyms: | ICAM1, BB2, CD54 antigen, CD54, ICAM-1, p3.58 |
Target Sequences: | NM_000201 NP_000192.2 P05362 |
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