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The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
Gene Name: | insulin-like growth factor 2 (somatomedin A) |
Family/Subfamily: | Hormone , not assigned-Hormone |
Synonyms: | IGF2, C11orf43, IGF-II, PP9974, Somatomedin-A |
Target Sequences: | NM_000612 NP_000603.1 P01344 |
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