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IGFBP3

insulin-like growth factor binding protein 3

IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Name: insulin-like growth factor binding protein 3
Synonyms: IGFBP3, Binding protein 29, Binding protein 53, BP-53, IGF-binding protein 3, IGFBP-3, IBP-3, IBP3
Target Sequences: NM_000598 NP_000589.2 P17936

Publications (2)

1
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy. Lui JC, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, Jee YH, Landman E, Nilsson O, Barnes KM, Baron J. Nature communications. 2016 7:13685. (WB; Human) [Full Text Article] [PubMed:27897169] Related Antibodies: LS-C407922.
2
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F Markmann, Emanuela Orsi, Jan Škrha Jr, Maria Gabriella Camboni, Reza Abdi, A M James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zu. Nature communications. 2022 February;13:684. [Full Text Article] [PubMed:35115561] [PMC:PMC8813914] Related Antibodies: LS-C340284.

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Antibodies (94)
ELISA Kits (40)
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IGFBP3 (154)
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IGFBP3 Antibody - IGFBP3 antibody IHC-paraffin. IHC(P): Human Intestinal Cancer Tissue.
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IGFBP3 Rabbit anti-Human Polyclonal (aa214-252) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
IGFBP3 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
IGFBP3 Rabbit anti-Human Polyclonal (aa130-179) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$441
IGFBP3 Antibody - Antibody (0.02 ug/ml) staining of Human Breast cancer lysate (35 ug protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
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IGFBP3 Goat anti-Human Polyclonal (aa191-205) Antibody
Mouse, Goat, Dog, Sheep, Bovine, Rat, Pig, Horse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
IGFBP3 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
54.87 - 40000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
IGFBP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
156.2 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
IGFBP3 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IGFBP3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IGFBP3.
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IGFBP3 Mouse anti-Human Monoclonal (aa28-297) (OTI3B9) Antibody
Human
WB
Unconjugated
100 µl/$434
IGFBP3 Antibody - Western blot of recombinant IGFBP3 / IGFBP-3.
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IGFBP3 Rabbit anti-Cow Polyclonal (aa106-241) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
IGFBP3 Antibody - Western blot of recombinant IGFBP3 / IGFBP-3.
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IGFBP3 Rabbit anti-Cow Polyclonal (aa106-241) (HRP) Antibody
Bovine, Cow
WB
HRP Conjugated
100 µl/$349; 200 µl/$407; 500 µl/$606; 1 ml/$757; 2 ml/$995; 5 ml/$1,721
IGFBP3 ELISA Kit
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Sandwich
96-Well Microplate
Human
74 - 18000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
IGFBP3 ELISA Kit
Select
Sandwich
96-Well Microplate
Pig
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
IGFBP3 Antibody - Anti-IGFBP3 antibody IHC of human liver, hephatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IGFBP3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
IGFBP3 Antibody - Biotinylated Anti-Human IGF-BP3 Western Blot Reduced
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IGFBP3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
IGFBP3 Antibody - Immunohistochemical analysis of IGFBP3 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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IGFBP3 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
IGFBP3 Antibody - IGFBP3 / IGFBP-3 antibody. IHC(P): Human Breast Cancer Tissue.
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IGFBP3 Rabbit anti-Human Polyclonal (aa182-198) Antibody
Goat, Guinea pig, Sheep, Bovine, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
IGFBP3 Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with IGFBP3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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IGFBP3 Rabbit anti-Rat Polyclonal (aa163-193) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
IGFBP3 Antibody - Western blot of recombinant IGFBP3 / IGFBP-3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IGFBP3 Rabbit anti-Mouse Polyclonal (aa151-291) Antibody
Mouse
WB
Unconjugated
100 µl/$273; 200 µl/$300; 500 µl/$390; 1 ml/$435; 2 ml/$524; 5 ml/$883
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IGFBP3 Rabbit anti-Human Monoclonal (Preservative Free) (010) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
Select
IGFBP3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
IGFBP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.94 - 60 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
IGFBP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
IGFBP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
IGFBP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
IGFBP3 Antibody
Select
IGFBP3 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$575
Select
E. coli
His
17.9 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
Viewing 1-25 of 154 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).