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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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IL-1B / IL-1 Beta
interleukin 1, beta
IL-1 Beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
| Gene Name: | interleukin 1, beta |
| Family/Subfamily: | IL-1 , not assigned-IL-1 |
| Synonyms: | IL1B, IL-1B, IL-1 beta, IL1-BETA, Preinterleukin 1 beta, Pro-interleukin-1-beta, Catabolin, IL-1, IL1F2, Interleukin 1, beta, Interleukin-1 beta |
| Target Sequences: | NM_000576 NP_000567.1 P01584 |
Publications (16)
1
Colorectal cancer chemoprevention by 2 beta-cyclodextrin inclusion compounds of auraptene and 4’-geranyloxyferulic acid. Takuji Tanaka, Mariangela B.M. de Azevedo, Nelson Dura´n, Joel B. Alderete, Francesco Epifano, Salvatore Genovese, Mayu Tanaka, Takahiro Tanaka, Massimo Curini. International journal of cancer. Journal international du cancer. 2010 126:830-40. (IHC-P; Mouse)
[Full Text Article]
[PubMed:19688830]
2
Trimeric form of intracellular ATP synthase subunit of Aggregatibacter actinomycetemcomitans binds human interleukin-1. Paino A, Tuominen H, Jskelinen M, Alanko J, Nuutila J, Asikainen SE, Pelliniemi LJ, Pllnen MT, Chen C, Ihalin R. PloS one. 2011 6:e18929.
[PubMed:21533109]
[PMC:PMC3078924]
3
Interleukin-1 is internalised by viable Aggregatibacter actinomycetemcomitans biofilm and locates to the outer edges of nucleoids. Paino A, Lohermaa E, Sormunen R, Tuominen H, Korhonen J, Pllnen MT, Ihalin R. Cytokine. 2012 60:565-74. (IHC, EM; Bacteria)
[PubMed:22898394]
☰ Filters
Products
Proteins
(80)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(76)
Target
IL-1B / IL-1 Beta
(80)
Application
Bind
(3)
ELISA
(3)
Func
(3)
SDS-PAGE
(3)
Product Group
Coronavirus Antibodies Proteins cDNAs
(80)
Cytokine Release Syndrome
(80)
Cytokine Release Syndrome Proteins
(80)
Format
Animal-free
(2)
Publications
No
(80)
Tag
10His, N-terminus + Myc, C-terminus
(1)
6His, N-terminus
(2)
6His-SUMO, N-terminus
(1)
GST
(2)
GST, N-terminus
(2)
His
(12)
His, C-Terminal
(1)
His, N-Terminal
(8)
His,C-terminus
(1)
His,N-terminus
(2)
His-GST
(1)
His-S
(1)
His-T7
(6)
Myc-DDK (Flag)
(3)
Species
Bovine
(4)
Chicken
(2)
Dog
(2)
Guinea pig
(3)
Horse
(2)
Human
(32)
Mouse
(19)
Pig
(2)
Rabbit
(1)
Rat
(6)
Rhesus monkey
(1)
Sheep
(3)
Zebrafish
(2)
Source
293F Cells
(2)
293T Cells
(1)
CHO Cells
(2)
E. coli
(60)
HEK 293 Cells
(6)
Wheat Germ Extract
(3)
Yeast
(2)
Purification
Purified
(32)
Supernatant
(1)
Low Endotoxin Level
Low endotoxin level
(28)
Biologically Active
Biologically active
(25)
Animal-free
Animal-free
(2)
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.5 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$370
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.3 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
E. coli
None
Biologically active
17.3 kDa
10 µg/$388; 100 µg/$1,359; 500 µg/$2,723
HEK 293 Cells
His, N-Terminal
~17 kDa (25 kDa reducing conditions)
10 µg/$289; 100 µg/$432; 250 µg/$726; 50 µg/$360
E. coli
His,N-terminus
Bind ELISA Func SDS-PAGE
Biologically active
The recombinant pro form of human IL1ß consisting of 280 amino acids and has a calculated molecular mass of 32.3 kDa. It migrates as an approximately 34 kDa band in SDS-PAGE under reducing conditions.
100 µg/$570; 1 mg/$3,016
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17 kDa (SDS-PAGE)
50 µg/$402; 10 µg/$304; 1 mg/$2,251
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.4 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.3 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
E. coli
None
Bind ELISA Func SDS-PAGE
Biologically active
The recombinant human IL1ß consisting of 154 amino acids migrates with an apparent molecular mass of 17 kDa as estimated in SDS-PAGE under reducing conditions.
100 µg/$633; 1 mg/$3,016; 20 µg/$325
E. coli
His
21.8 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Yeast
His
19.7 kD
1 mg/$1,973; 100 µg/$679; 20 µg/$429
E. coli
None
Less than 0.1 EU/µg protein (determined by LAL method).
~17kDa (SDS-PAGE)
10 µg/$361
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.3 kDa (SDS-PAGE)
50 µg/$551; 10 µg/$304; 1 mg/$2,251
E. coli
His, N-Terminal
19.3 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261; 10 µg/$238; 50 µg/$304; 250 µg/$523
E. coli
None
Biologically active
17.3 kDa
10 µg/$388; 100 µg/$1,186; 500 µg/$2,269
E. coli
None
Biologically active
17.3 kDa
10 µg/$388; 100 µg/$1,359; 500 µg/$2,723
E. coli
None
Biologically active
17.5 kDa
10 µg/$388; 100 µg/$1,186; 500 µg/$2,269
Wheat Germ Extract
GST
55.33 kDa
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST
57.1 kDa
10 µg/$479; 25 µg/$670
None
Biologically active
17.5 kD
10 µg/$476
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.4kD
10 µg/$321; 50 µg/$534; 500 µg/$1,185; 1 mg/$1,535
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