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IL-1B / IL-1 Beta

interleukin 1, beta

IL-1 Beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Gene Name: interleukin 1, beta
Family/Subfamily: IL-1 , not assigned-IL-1
Synonyms: IL1B, IL-1B, IL-1 beta, IL1-BETA, Preinterleukin 1 beta, Pro-interleukin-1-beta, Catabolin, IL-1, IL1F2, Interleukin 1, beta, Interleukin-1 beta
Target Sequences: NM_000576 NP_000567.1 P01584

Publications (16)

1
Colorectal cancer chemoprevention by 2 beta-cyclodextrin inclusion compounds of auraptene and 4’-geranyloxyferulic acid. Takuji Tanaka, Mariangela B.M. de Azevedo, Nelson Dura´n, Joel B. Alderete, Francesco Epifano, Salvatore Genovese, Mayu Tanaka, Takahiro Tanaka, Massimo Curini. International journal of cancer. Journal international du cancer. 2010 126:830-40. (IHC-P; Mouse) [Full Text Article] [PubMed:19688830]
2
Trimeric form of intracellular ATP synthase subunit of Aggregatibacter actinomycetemcomitans binds human interleukin-1. Paino A, Tuominen H, Jskelinen M, Alanko J, Nuutila J, Asikainen SE, Pelliniemi LJ, Pllnen MT, Chen C, Ihalin R. PloS one. 2011 6:e18929. [PubMed:21533109] [PMC:PMC3078924]
3
Interleukin-1 is internalised by viable Aggregatibacter actinomycetemcomitans biofilm and locates to the outer edges of nucleoids. Paino A, Lohermaa E, Sormunen R, Tuominen H, Korhonen J, Pllnen MT, Ihalin R. Cytokine. 2012 60:565-74. (IHC, EM; Bacteria) [PubMed:22898394]
4
Serum soluble interleukin 7 receptor is strongly associated with lupus nephritis in patients with systemic lupus erythematosus. Badot V, Luijten RK, van Roon JA, Depresseux G, Aydin S, Van den Eynde BJ, Houssiau FA, Lauwerys BR. Annals of the rheumatic diseases. 2013 72:453-6. (IHC-Fr; Human) [PubMed:23264357] Related Antibodies: LS-C18827.
5
Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo. Smolders S, Smolders SM, Swinnen N, Gärtner A, Rigo JM, Legendre P, Brône B. Frontiers in cellular neuroscience. 2015 9:301. (Flo; Mouse) [Full Text Article] [PubMed:26300736] [PMC:PMC4525016]
6
Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats. Mocanu AO, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, Brethauer SA, Dinischiotu A, Kirwan JP. PloS one. 2015 10:e0139764. (IHC; Rat) [Full Text Article] [PubMed:26437377] [PMC:PMC4593548] Related Antibodies: LS-C104781.
7
Autophagy Mediates Interleukin-1ß Secretion in Human Neutrophils. Iula L, Keitelman IA, Sabbione F, Fuentes F, Guzman M, Galletti JG, Gerber PP, Ostrowski M, Geffner JR, Jancic CC, Trevani AS. Frontiers in immunology. 2018 February;9:269. (Human) [Full Text Article] [PubMed:29515581] [PMC:PMC5825906]
8
Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells. Yang Liu, Min Zhu, Ruowen Gong, Xin Wang, Lei Li, Gezhi Xu. Frontiers in cell and developmental biology. 2020 August;8:608. [Full Text Article] [PubMed:32733897] [PMC:PMC7363772]
9
Cold-induced urticarial autoinflammatory syndrome related to factor XII activation. Jörg Scheffel, Niklas A Mahnke, Zonne L M Hofman, Steven de Maat, Jim Wu, Hanna Bonnekoh, Reuben J Pengelly, Sarah Ennis, John W Holloway, Marieluise Kirchner, Philipp Mertins, Martin K Church, Marcus Maurer, Coen Maas, Karoline Krause. Nature communications. 2020 Jan;11:179. [Full Text Article] [PubMed:31924766] [PMC:PMC6954242] Related Antibodies: LS-C174781.
10
Effects of arginase inhibition via jugular infusion of N?-hydroxy-nor-l-arginine on metabolic and immune indices in lactating dairy cows. L Y Ding, Y F Wang, Y Z Shen, G Zhou, X Zhang, M Z Wang, J J Loor, J Zhang. Journal of dairy science. 2019 Apr;102:3310-3320. [Full Text Article] [PubMed:30738683]
11
Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (g/g) in a Surgically Induced Osteoarthritic Rabbit Model. Beom-Rak Choi, Su-Jin Kang, Jong-Lae Kim, Young-Joon Lee, Sae-Kwang Ku. Nutrients. 2020 Mar;12:852. [Full Text Article] [PubMed:32235804] [PMC:PMC7146119]
12
Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-?B) pathway. Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan, Xiuwei Zhang. Bioengineered. 2022 April;13:10098-10110. [Full Text Article] [PubMed:35435119] [PMC:PMC9162013] Related Antibodies: LS-C104781.
13
Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]
14
Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]
15
p65-Dependent production of interleukin-1 beta by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts. Schulze J, Weber K, Baranowsky A, Streichert T, Lange T, Spiro AS, Albers J, Seitz S, Zustin J, Amling M, Fehse B, Schinke T. Cancer letters. 2012 Apr;317:106-13. [Full Text Article] [PubMed:22108531] Related Antibodies: LS-C18827.
16
Ontogeny and the effects of in utero brain ischemia on interleukin-1 beta and interleukin-6 protein expression in ovine cerebral cortex and white matter. Sadowska GB, Threlkeld SW, Flangini A, Sharma S, Stonestreet BS. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2012 Oct;30:457-63. [Full Text Article] [PubMed:22698958] [PMC:PMC3438310] Related Antibodies: LS-C42757.
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Proteins (80)
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IL-1B / IL-1 Beta (80)
Bind (3)
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No (80)
10His, N-terminus + Myc, C-terminus (1)
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.5 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.3 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
IL-1B / IL-1 Beta Protein
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E. coli
None
Biologically active
17.3 kDa
10 µg/$388; 100 µg/$1,359; 500 µg/$2,723
IL-1B / IL-1 Beta Protein
Select
HEK 293 Cells
His, N-Terminal
~17 kDa (25 kDa reducing conditions)
10 µg/$289; 100 µg/$432; 250 µg/$726; 50 µg/$360
IL-1B / IL-1 Beta Protein - Measured by its binding ability in a functional ELISA. Immobilized human IL1B at 10 µg/mL (100 µl/well) can bind human IL1R1. The EC50 of human IL1R1 is 0.198 µg/mL.
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E. coli
His,N-terminus
Bind ELISA Func SDS-PAGE
Biologically active
The recombinant pro form of human IL1ß consisting of 280 amino acids and has a calculated molecular mass of 32.3 kDa. It migrates as an approximately 34 kDa band in SDS-PAGE under reducing conditions.
100 µg/$570; 1 mg/$3,016
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CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17 kDa (SDS-PAGE)
50 µg/$402; 10 µg/$304; 1 mg/$2,251
Select
E. coli
His
21.8 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Select
None
23 kD
50 µg/$491
IL-1B / IL-1 Beta Protein - Using the Octet RED System, the affinity constant (Kd) of IL1R2 Protein, Human, Recombinant (Fc Tag) bound IL-1 beta Protein, Human, Recombinant was 6.0 nM.
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E. coli
None
Bind ELISA Func SDS-PAGE
Biologically active
The recombinant human IL1ß consisting of 154 amino acids migrates with an apparent molecular mass of 17 kDa as estimated in SDS-PAGE under reducing conditions.
100 µg/$633; 1 mg/$3,016; 20 µg/$325
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.3 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.4 kDa
2 µg/$268; 10 µg/$349
IL-1B / IL-1 Beta Protein
Select
Yeast
His
19.7 kD
1 mg/$1,973; 100 µg/$679; 20 µg/$429
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.3 kDa (SDS-PAGE)
50 µg/$551; 10 µg/$304; 1 mg/$2,251
IL-1B / IL-1 Beta Protein - Recombinant Interleukin 1 Beta By SDS-PAGE
Select
E. coli
His, N-Terminal
19.3 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Select
E. coli
None
Less than 0.1 EU/µg protein (determined by LAL method).
~17kDa (SDS-PAGE)
10 µg/$361
IL-1B / IL-1 Beta Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
29.9 kDa
20 µg/$364; 1 mg/$1,679; 100 µg/$500
IL-1B / IL-1 Beta Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus + Myc, C-terminus
32.9 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
IL-1B / IL-1 Beta Protein - D10.G4.1 cell proliferation induced by mouse IL-1β.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 152 amino acid recombinant protein has a predicted molecular mass of 17,394 Da. The DTT-reduced and the non-reduced protein migrate at approximately 19kDa by SDS-PAGE. The N-terminal amino acid is Valine.
10 µg/$344; 25 µg/$436; 100 µg/$969; 500 µg/$2,133
IL-1B / IL-1 Beta Protein - Recombinant human IL-1β stimulates proliferation of D10.G4.1 cells in a dose-dependent manner. BioLegend€™s protein was compared side-by-side to a competitor€™s equivalent product. The ED50 for this effect is 5 €“ 15 pg/mL.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 153 amino acid recombinant protein has a predicted molecular mass of 17,376 Da. The DTT-reduced and the non-reduced protein migrate at approximately 18kDa by SDS-PAGE. The N-terminal amino acid is Alanine.
10 µg/$344; 25 µg/$436; 100 µg/$1,144; 500 µg/$2,133
IL-1B / IL-1 Beta Protein - Recombinant Dog interleukin-1 beta detected using Rabbit anti Dog interleukin-1 beta as the capture reagent and Rabbit anti Dog interleukin-1 beta:Biotin as the detection reagent followed by Streptavidin:HRP.
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Yeast
None
17.5 kDa
5 µg/$390
Select
E. coli
None
17.5 kDa
20 µg/$360; 100 µg/$728
Select
E. coli
None
17.4 kDa
20 µg/$428; 100 µg/$1,129
IL-1B / IL-1 Beta Protein - Recombinant Interleukin 1 Beta (IL1b) by SDS-PAGE
Select
E. coli
His, N-Terminal
21kDa
10 µg/$291; 50 µg/$502; 200 µg/$1,002; 100 µg/$802; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
IL-1B / IL-1 Beta Protein - Eukaryotic Interleukin 1 Beta (IL1b) by SDS-PAGE
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293F Cells
His, N-Terminal
19kDa
10 µg/$275; 50 µg/$402; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
IL-1B / IL-1 Beta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).