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IL-33
interleukin 33
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).
| Gene Name: | interleukin 33 |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL33, C9orf26, DVS27, DVS27-related protein, IL-1F11, IL-33, Interleukin-33, NFEHEV, NF-HEV, Interleukin-1 family member 11, NFHEV, IL1F11, Interleukin 33, RP11-575C20.2 |
| Target Sequences: | NM_033439 NP_254274.1 O95760 |
Publications (5)
1
Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa. Wang W, Li Y, Lv Z, Chen Y, Li Y, Huang K, Corrigan CJ, Ying S. Journal of immunology (Baltimore, Md. : 1950). 2018 October;201:2221-2231. [Full Text Article]
[PubMed:30185520]
Related Antibodies: LS-C104697.
2
Matrix bound nanovesicle-associated IL-33 activates a pro-remodeling macrophage phenotype via a non-canonical, ST2-independent pathway. George S Hussey, Jenna L Dziki, Yoojin C Lee, Joseph G Bartolacci, Marissa Behun, Heth R Turnquist, Stephen F Badylak. Journal of immunology and regenerative medicine. 2019 March;3:26-35. [Full Text Article]
[PubMed:31656879]
[PMC:PMC6814021]
3
A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes. Eva Haas , Rana D Incebacak , Thomas Hentrich , Chrisovalantou Huridou , Thorsten Schmidt , Nicolas Casadei , Yacine Maringer , Carola Bahl , Frank Zimmermann, James D Mills, Eleonora Aronica, Olaf Riess , Julia M Schulze-Hentrich , Jeannette Hübener-Schmid. Molecular neurobiology. 2022 Jan;;59:495-522. [Full Text Article]
[PubMed:34716557]
[PMC:PMC8786755]
Related Antibodies: LS-C294906.
☰ Filters
Products
Proteins
(38)
Type
Over-Expression Lysate
(2)
Recombinant
(36)
Target
IL-33
(38)
Format
Animal-free
(1)
Publications
No
(38)
Tag
6His, N-terminus
(2)
GST
(3)
GST, N-terminus
(1)
His
(7)
His, N-Terminal
(2)
His,N-terminus
(1)
His-T7
(1)
Myc-DDK (Flag)
(2)
Species
Human
(21)
Monkey-Rhesus
(1)
Mouse
(12)
Pig
(1)
Rat
(2)
Source
293T Cells
(1)
E. coli
(34)
HEK 293 Cells
(1)
Wheat Germ Extract
(2)
Purification
Purified
(12)
Low Endotoxin Level
Low endotoxin level
(25)
Biologically Active
Biologically active
(11)
Animal-free
Animal-free
(1)
E. coli
His, N-Terminal
34.6 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.9 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$370
E. coli
GST
45 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
293T Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$150
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 158 amino acid recombinant protein has a predicted molecular mass of approximately 17,554 Da. The DTT-reduced and non-reduced protein migrate at approximately 20 kDa by SDS-PAGE. The N-terminal amino acid is Serine.
10 µg/$344; 25 µg/$459; 100 µg/$1,000; 500 µg/$2,235
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~18 kDa
10 µg/$291; 100 µg/$731; 1 mg/$2,851
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$411; 250 µg/$769; 10 µg/$276; 20 µg/$332; 100 µg/$544; 500 µg/$985
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$759; 20 µg/$519
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.5 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
17.9 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
E. coli
None
Biologically active
17.5 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
GST
43.3 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
E. coli
His-T7
21.5 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
His
13.1 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
His
18.5 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Wheat Germ Extract
GST
57.2 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
100 µg/$494
E. coli
His, N-Terminal
30.6 kDa
50 µg/$419
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
17.5 kDa
10 µg/$364; 1 mg/$4,545
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.6 kDa
50 µg/$516; 10 µg/$313; 1 mg/$2,837; 500 µg/$1,987
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 159 amino acid recombinant protein has a predicted molecular mass of approximately 18 kD. The DTT-reduced protein migrates at approximately 19 kD and non-reduced protein migrates at approximately 20 kD by SDS-PAGE. The N-terminal amino acid is Serine.
10 µg/$359; 25 µg/$474; 100 µg/$1,097; 500 µg/$2,336
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
~18kDa (SDS-PAGE)
50 µg/$484; 10 µg/$302
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
~20kDa (SDS-PAGE)
50 µg/$484; 10 µg/$302
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product results
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