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Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Gene Name: | interleukin 10 receptor, beta |
Family/Subfamily: | Interleukin |
Synonyms: | IL10RB, CDW210B, CDw210b antigen, D21S66, IL-10R subunit 2, IBD25, IL-10R2, Interleukin 10 receptor, beta, IL-10 receptor subunit beta, IL-10R subunit beta, IL-10RB, CRF2-4, CRFB4, D21S58 |
Target Sequences: | NM_000628 NP_000619.3 Q08334 |
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