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IL17A

interleukin 17A

IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Gene Name: interleukin 17A
Family/Subfamily: Interleukin
Synonyms: IL17A, CTLA-8, CTLA8, Interleukin-17A, Interleukin 17A, IL-17, IL-17A, IL17
Target Sequences: NM_002190 NP_002181.1 Q16552

Publications (3)

1
Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis. Roth S, Spalinger MR, Gottier C, Biedermann L, Zeitz J, Lang S, Weber A, Rogler G, Scharl M. PloS one. 2016 11:e0154817. (IHC; Human) [Full Text Article] [PubMed:27152519] [PMC:PMC4859486] Related Antibodies: LS-B8323.
2
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. Sherrie J Divito, Anders T Aasebø, Tiago R Matos, Pei-Chen Hsieh, Matthew Collin, Christopher P Elco, John T O'Malley, Espen S Bækkevold, Henrik Reims, Tobias Gedde-Dahl, Michael Hagerstrom, Jude Hilaire, John W Lian, Edgar L Milford, Geraldine S Pinkus, Vincent T Ho, Robert J Soiffer, Haesook T Kim, Martin C Mihm, Jerome Ritz, Indira Guleria, Corey S Cutler, Rachael A Clark, Frode L Jahnsen, Thomas S Kupper. The Journal of clinical investigation. 2020 September;130:4624-4636. [Full Text Article] [PubMed:32516138] [PMC:PMC7456221] Related Antibodies: LS-C104427.
3
Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions. E Hagforsen, M Lampinen, A Paivandy, S Weström, H Velin, S Öberg, G Pejler, O Rollman. The British journal of dermatology. 2017 July;177:179-187. [Full Text Article] [PubMed:28117878] Related Antibodies: LS-B7397.

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Antibodies (128)
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IL17A Antibody - Anti-IL-17 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-10 ug/ml.
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Neuroscience
IL17A Mouse anti-Human Monoclonal (aa1-75) (4K5F6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$440
IL17A Antibody - Anti-IL-17 antibody IHC of human t lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IL17A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
IL17A Antibody - Direct ELISA of IL-17 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL17A Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$325; 50 µg/$361
IL17A Antibody - Western Blot (non-reducing) of IL-17 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL17A Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
IL17A Antibody - Western Blot (non-reducing) of IL-17 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL17A Goat anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$325; 50 µg/$361
IL17A Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IL17A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
IL17A Antibody - Immunohistochemistry - Anti-IL17 Picoband Antibody
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IL17A Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$421
IL17A Antibody - Biotin Rabbit Anti-Rat IL-17A Antibody - Western Blot. Western Blot showing detection of Rat IL-17A. 50 ng of Rat IL-17A (Lane 1) was run on a 4-20% gel and transferred to 0.45 micron nitrocellulose. After blocking with 5% Blotto (B501-0500) 30 min at 20?, Anti-Rat IL-17A (RABBIT) Antibody Biotin Conjugated Anti-Rat IL-17A (RABBIT) Antibody Biotin Conjugated - 212-406-B32 secondary antibody was used at 1:5000 in Blocking Buffer for Fluorescent Western Blot (p/n MB-070). HRP Streptavidin (p/n S000-03) was used at 1:40000 in MB-070 for 30 min at 20? and imaged using the Bio-Rad VersaDoc 4000 MP. Arrow indicates correct 15 kD molecular weight position expected for Rat IL-17A. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL17A Rabbit anti-Rat Polyclonal (Biotin) Antibody
Mouse, Rat
ELISA, IHC, WB
Biotin Conjugated
100 µg/$499
IL17A Antibody - ELISA using IL-17A Antibody (3-36.2.7.3)
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IL17A Mouse anti-Human Monoclonal (3-36.2.7.3) Antibody
Human
ELISA
Unconjugated
200 µg/$503
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IL17A Mouse anti-Human Monoclonal (PE) (41802) Antibody
Human
Flo
PE Conjugated
100 Tests/$756
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IL17A Mouse anti-Human Monoclonal (PE) (BL168) Antibody
Human
Flo
PE Conjugated
20 Tests/$236; 50 Tests/$259; 100 Tests/$294; 200 Tests/$341
IL17A Antibody - Untreated (A) and PMA/ionomycin -stimulated (B) human PBMCs were stained using PE-conjugated mouse anti-human CD3 antibody and APC-conjugated antibody Interleukin 17 (IL-17, CTLA8, IL-17A,  Interleukin-17A precursor, Cytotoxic T-lymphocyte-associated antigen 8) (APC) This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL17A Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$756
IL17A ELISA Kit
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Sandwich
96-Well Strip Plate
Hamster
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
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IL17A Mouse anti-Human Monoclonal (aa25-155) Antibody
Human
ELISA
Unconjugated
100 µl/$425
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IL17A Mouse anti-Human Monoclonal (3.41.2.6.1) Antibody
Human
ELISA
Unconjugated
200 µg/$503
IL17A Antibody - Anti-IL-17A Antibody - Western Blot. Western blot of anti-IL-17A antibody shows detection of rat recombinant IL-17A protein (lane 1). Approximately 2 ug of recombinant protein was loaded onto the gel. Primary antibody was used at a 1:1000 dilution. The membrane was washed and reacted with a 1:20000 dilution of DyLight 649 conjugated Gt-a-Rabbit IgG (. Molecular weight estimation was made by comparison to prestained MW markers indicated at the left. Other detection systems will yield similar results.
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IL17A Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µg/$498
IL17A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$653
IL17A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$649
IL17A Antibody - Western Blot (non-reducing) of IL-17 antibody
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IL17A Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
IL17A Antibody - Western blot of Mouse Anti-IL-17A antibody Lane 1: human full length recombinant IL-17A protein Lane 2: mouse full length recombinant IL-17A protein Lane 3: rat full length recombinant IL-17A protein Load: 20 ng/lane Primary antibody: Anti-IL-17A antibody at 1 ug/mL for overnight at 4C This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL17A Mouse anti-Human Monoclonal (Biotin) (4H1524.1) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
100 µg/$499
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IL17A Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
100 µg/$499
IL17A Antibody - Western blot - Anti-IL-17 Antibody
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IL17A Rabbit anti-Mouse Polyclonal (aa26-158) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$421
IL17A Antibody - Western blot analysis of extracts of various cell lines, using IL17A antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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IL17A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
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IL17A Rat anti-Mouse Monoclonal Antibody
Mouse
ELISA, Flo, IF, WB
Unconjugated
500 µg/$528
IL17A Antibody - IL17A / IL-17 antibody Western blot of MCF7 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL17A Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Goat, Dog, Bovine, Horse, Gibbon, Human
WB
FITC Conjugated
100 µl/$459
Viewing 1-25 of 219 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).