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IL25 / IL17E

interleukin 25

The IL17 proteins are a family of potent cytokines that act to induce proinflammatory responses. Studies have shown that IL17E binds strongly to IL17RB. Receptor binding of ligand has been shown to lead to the activation of nuclear factor kappa-B and production of IL8. Exposure of mice to IL17 resulted in a Th-2 like response characterized by increased serum IgE, IgG1 and IgA levels, blood eosinophilia, increased lymphocytes and neutrophils, and pathological changes in the tissues that included eosinophilic infiltrates, increased mucus production, B-lymphocyte hyperplasia and epithelial cell hyperplasia/hypertrophy.

Gene Name: interleukin 25
Family/Subfamily: Interleukin
Synonyms: IL25, Interleukin 17E, Interleukin 25, Interleukin-25, IL17E, IL-17E, IL-25, Interleukin-17E
Target Sequences: NM_022789 NP_073626.1 Q9H293

Publications (3)

1
Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome. Terrier B, Bièche I, Maisonobe T, Laurendeau I, Rosenzwajg M, Kahn JE, Diemert MC, Musset L, Vidaud M, Sène D, Costedoat-Chalumeau N, Le Thi-Huong D, Amoura Z, Klatzmann D, Cacoub P, Saadoun D. Blood. 2010 116:4523-31. (WB; Human) [Full Text Article] [PubMed:20729468] Related Antibodies: LS-B123.
2
Elevations in Th2-initiating cytokines (IL-33, IL-25, TSLP) in lesional skin from Chronic Spontaneous ("Idiopathic") Urticaria. Clark P, Maurer M, Ying S. The British journal of dermatology. Dec; [Full Text Article] [PubMed:25523947] Related Antibodies: LS-C165200.
3
Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa. Wang W, Li Y, Lv Z, Chen Y, Li Y, Huang K, Corrigan CJ, Ying S. Journal of immunology (Baltimore, Md. : 1950). 2018 October;201:2221-2231. [Full Text Article] [PubMed:30185520] Related Antibodies: LS-C165200.

☰ Filters
Products
Proteins (19)
Over-Expression Lysate (4)
Recombinant (15)
IL25 / IL17E (19)
Animal-free (1)
No (19)
6His, C-terminus (2)
6His, N-terminus (1)
Fc, N-terminus (1)
GST (1)
His (1)
His, N-Terminal (1)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Human (12)
Mouse (3)
Rat (2)
293T Cells (2)
E. coli (9)
HEK 293 Cells (4)
Human Cells (1)
Insect Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (6)
Low endotoxin level (9)
Biologically active (4)
Animal-free (1)
IL25 / IL17E Protein - Recombinant  Interleukin 25 By SDS-PAGE
Select
E. coli
His-T7
19.5 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
IL25 / IL17E Protein - Purified recombinant protein IL25 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
16.7 kDa
20 µg/$1,107
IL25 / IL17E Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
16.7 kDa
20 µg/$150
IL25 / IL17E Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
20.3 kDa
20 µg/$150
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
33.8 kDa
5 µg/$268; 25 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 25 µg/$370
IL25 / IL17E Protein - Recombinant Interleukin 25 By SDS-PAGE
Select
E. coli
His-GST
43.4 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
IL25 / IL17E Protein - Recombinant Interleukin 25 By SDS-PAGE
Select
E. coli
His
18.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18kD
10 µg/$243; 50 µg/$288; 500 µg/$1,262; 1 mg/$1,627
IL25 / IL17E Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
16.7 kDa
100 µg/$494
IL25 / IL17E Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
20.3 kDa
100 µg/$494
IL25 / IL17E Protein - Active Interleukin 25 (IL25) by WB
Select
E. coli
His, N-Terminal
21kDa
10 µg/$307; 50 µg/$602; 200 µg/$1,156; 100 µg/$962; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562
IL25 / IL17E Protein - The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be <0.5ng/mL.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~16 kDa
10 µg/$291; 100 µg/$834; 1 mg/$3,025
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.7kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
IL25 / IL17E Protein - 12.5% SDS-PAGE of human IL17E stained with Coomassie Blue
Select
Wheat Germ Extract
GST
46.7 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
None
Less than 0.1 ng/µg of protein.
The 146 amino acid recombinant protein has a predicted molecular mass of approximately 17 kD. Recombinant human IL-17E forms a non-disulfide-linked homodimer (34 kD). The predicted N-terminal amino acid is Met.
5 µg/$272; 25 µg/$352
IL25 / IL17E Protein - Mouse IL-25 induces CXCL1/GRO alpha in HT-29 human colon adenocarcinoma cells.
Select
Insect Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 153 amino acid recombinant protein has a predicted molecular mass of 17.6 kD. This protein exists as a disulfide-linked homodimer. The DTT-reduced protein migrates at approximately 20 kD by SDS-PAGE. The non-reduced protein migrates as a homodimer, at
10 µg/$359; 25 µg/$439; 100 µg/$749
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.7 kDa
10 µg/$288; 50 µg/$436
Select
HEK 293 Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.1 kDa
50 µg/$556
Viewing 1-19 of 19 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).