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IL2RB / CD122

interleukin 2 receptor, beta

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

Gene Name: interleukin 2 receptor, beta
Family/Subfamily: Interleukin
Synonyms: IL2RB, CD122, CD122 antigen, IL-2 receptor subunit beta, IL15RB, Interleukin 15 receptor, beta, p70-75, IL-2R subunit beta, IL-2RB, Interleukin 2 receptor, beta
Target Sequences: NM_000878 NP_000869.1 P14784

☰ Filters
Products
Proteins (25)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (21)
IL2RB / CD122 (25)
Bind (2)
ELISA (1)
Func (1)
SDS-PAGE (4)
Product Group
Coronavirus Antibodies Proteins cDNAs (22)
Cytokine Release Syndrome (22)
Cytokine Release Syndrome Proteins (22)
No (25)
6His, C-terminus (3)
6His, N-terminus (3)
AVI-6His, C-terminus (1)
Fc (1)
Fc, C-terminus (3)
His (4)
His, N-Terminal (3)
His,C-terminus (3)
Human IgG Fc, C-terminus (1)
Myc-DDK (Flag) (2)
Human (15)
Mouse (8)
Rat (1)
293T Cells (1)
Baculovirus (1)
E. coli (5)
HEK 293 Cells (7)
Human (3)
Human Cells (5)
Mammalian Cells (2)
Yeast (1)
Purified (4)
Low endotoxin level (14)
Biologically active (3)
Select
E. coli
6His, N-terminus
29.4 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
IL2RB / CD122 Protein - Active Interleukin 2 Receptor Beta (IL2Rb) by WB
Select
E. coli
His, N-Terminal
27kDa
10 µg/$339; 50 µg/$802; 200 µg/$1,430; 100 µg/$1,214; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
IL2RB / CD122 Protein - Recombinant Interleukin 2 Receptor Beta By SDS-PAGE
Select
E. coli
His
26.4 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
IL2RB / CD122 Protein
Select
Yeast
His
27.3 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
Select
HEK 293 Cells
6His, N-terminus
25 kDa
100 µg/$298
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
51.7kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
IL2RB / CD122 Protein
Select
E. coli
His
26.6 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Select
HEK 293 Cells
6His, N-terminus
25 kDa
200 µl/$283
IL2RB / CD122 Protein - Using the Octet RED System, the affinity constant (Kd) of CD122 / IL2RB Protein, Human, Recombinant (Fc Tag) bound to IgG1 Antibody was 0.3 µM.
Select
HEK 293 Cells
Human IgG Fc, C-terminus
Bind SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human IL2 Rß/Fc is a disulfide-linked homodimeric protein generated after removal of the signal peptide. The reduced monomer consists of 451 amino acids and has a predicted molecular mass of 51.6 kDa. As a result of glycosylation, the apparent molecular mass of rh IL2RB/Fc monomer is approximately 60-65 kDa in SDS-PAGE under reducing conditions.
100 µg/$519; 1 mg/$2,551
IL2RB / CD122 Protein
Select
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The mature recombinant human IL2 Rß consists of 219 amino acids and has a predicted molecular mass of 25.2 kDa. As a result of glycosylation, the rh IL2 Rß migrates as an approximately 40 kDa protein in SDS-PAGE under reducing conditions.
100 µg/$570
IL2RB / CD122 Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse IL2RB comprises 225 amino acids and has a predicted molecular mass of 26.5 kDa. The apparent molecular mass of the protein is approximately 45-54 kDa in SDS-PAGE under reducing conditions.
50 µg/$441; 1 mg/$2,675
IL2RB / CD122 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
61.12 kDa
20 µg/$150
IL2RB / CD122 Protein - Recombinant Interleukin 2 Receptor Beta (IL2Rb) by SDS-PAGE
Select
E. coli
His, N-Terminal
26.2kDa
10 µg/$276; 50 µg/$412; 200 µg/$822; 100 µg/$657; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
IL2RB / CD122 Protein - Recombinant Mouse IL-2 Receptor Subunit Beta/IL-2RB/CD122 (C-Fc)
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.2 kDa
10 µg/$388; 50 µg/$875
IL2RB / CD122 Protein - Recombinant Mouse IL-2 Receptor Subunit Beta/IL-2RB/CD122 (C-6His)
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.1 kDa
10 µg/$388; 50 µg/$875
IL2RB / CD122 Protein - Recombinant Human IL-2 Receptor Subunit Beta/IL-2RB/CD122 (C-6His-Avi) Biotinylated
Select
Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27.4 kDa
20 µg/$416; 100 µg/$910
IL2RB / CD122 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
61.12 kDa
100 µg/$494
IL2RB / CD122 Protein - Measured by its ability to inhibit IL-15-dependent proliferation of MO7e human megakaryocytic leukemic cells in the presence of 4 ng/mL of recombinant human IL-15. The ED50 for this effect is typically 2-10 µg/mL.
Select
Baculovirus
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human IL2RB consists of 224 amino acids and predicts a molecular mass of 26 kDa.
100 µg/$519; 1 mg/$3,057
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
51.7 kDa
10 µg/$317; 50 µg/$524
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.6 kDa
10 µg/$317; 50 µg/$524
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
51.6 kDa
100 µg/$1,187; 1 mg/$5,983
Select
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
25.2 kDa
100 µg/$1,187
IL2RB / CD122 Protein
Select
HEK 293 Cells
His, N-Terminal
25 kDa (35 kDa reducing conditions)
10 µg/$289; 50 µg/$360
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26.5 kDa
50 µg/$854; 1 mg/$6,025
Viewing 1-25 of 25 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).