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IL4
interleukin 4
IL4 is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
| Gene Name: | interleukin 4 |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | IL4, B cell growth factor 1, B-cell stimulatory factor 1, B_cell stimulatory factor 1, BCGF1, BSF-1, Binetrakin, BCGF-1, Interleukin 4, Interleukin-4, Pitrakinra, BSF1, IL-4 |
| Target Sequences: | NM_000589 NP_000580.1 P05112 |
Publications (3)
1
Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Gong G, Shao L, Wang Y, Chen CY, Huang D, Yao S, Zhan X, Sicard H, Wang R, Chen ZW. Blood. 2009 113:837-45.
[PubMed:18981295]
[PMC:PMC2630269]
Related Antibodies: LS-C41019.
2
Modulation of Binge-like Ethanol Consumption by IL-10 Signaling in the Basolateral Amygdala. S Alex Marshall, Kyle H McKnight, Allyson K Blose, Donald T Lysle, Todd E Thiele. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2017 June;12:249-259. [Full Text Article]
[PubMed:27640210]
[PMC:PMC5357210]
Related Antibodies: LS-C745952.
3
Delivery of Interleukin-4-Encoding Lentivirus Using Multiple-Channel Bridges Enhances Nerve Regeneration. S Ahmed Ali, John E Hanks, Aaron W Stebbins, Osama Alkhalili, Samantha T Cohen, Jessica Y Chen, Dominique R Smith, Courtney M Dumont, Lonnie D Shea, Norman D Hogikyan, Eva L Feldman, Michael J Brenner. The Laryngoscope. 2020 December;130:2802-2810. [Full Text Article]
[PubMed:32220076]
[PMC:PMC7893531]
Related Antibodies: LS-C408858.
☰ Filters
Products
Proteins
(72)
Type
Over-Expression Lysate
(2)
Recombinant
(70)
Target
IL4
(72)
Format
Animal-free
(2)
Publications
No
(72)
Tag
10His-B2M, N-terminus + Myc, C-terminus
(1)
6His, C-terminus
(5)
6His, N-terminus
(3)
6His-SUMO, N-terminus
(1)
Fc, C-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(9)
His, C-Terminal
(1)
His, N-Terminal
(5)
His,C-terminus
(1)
His-GST
(2)
His-T7
(3)
Human IgG1 Fc, C-terminus
(1)
Human Mutant IgG1 Fc
(1)
Mouse Mutant IgG2a Fc
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Chicken
(1)
Crab-eating macaque
(1)
Dog
(2)
Human
(38)
Mouse
(16)
Pig
(3)
Rabbit
(2)
Rat
(4)
Rhesus monkey
(1)
Sheep
(2)
Source
293F Cells
(2)
293T Cells
(1)
CHO Cells
(7)
E. coli
(36)
HEK 293 Cells
(6)
Human
(4)
Human Cells
(2)
Mammalian Cells
(5)
Wheat Germ Extract
(2)
Yeast
(4)
Purification
Purified
(24)
Low Endotoxin Level
Low endotoxin level
(38)
Biologically Active
Biologically active
(25)
Animal-free
Animal-free
(2)
CHO Cells
Human IgG1 Fc, C-terminus
Less than 0.06 EU/µg protein (determined by LAL method).
43 kDa (predicted)
50 µg/$428; 10 µg/$337
Yeast
6His, N-terminus
1 mg/$1,973; 100 µg/$679; 20 µg/$429
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15 kDa (SDS-PAGE)
50 µg/$342; 10 µg/$286; 1 mg/$1,612
E. coli
None
Biologically active
14.9 kDa
5 µg/$267; 20 µg/$351; 100 µg/$874; 250 µg/$1,382; 1 mg/$2,839; 500 µg/$1,917
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
13.4 kDa
50 µg/$487; 10 µg/$303; 1 mg/$2,837; 500 µg/$1,987
HEK 293 Cells
Myc-DDK (Flag)
14.9 kDa
20 µg/$1,107
E. coli
None
Biologically active
13.5 kDa
5 µg/$282; 100 µg/$1,030; 500 µg/$1,891
HEK 293 Cells
His
15.5 kDa
10 µg/$323; 50 µg/$702; 100 µg/$1,043
E. coli
His, N-Terminal
16.2 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15 kDa (SDS-PAGE)
50 µg/$551; 10 µg/$304; 1 mg/$3,157
Yeast
6His, N-terminus
14.6 kDa
100 µg/$679; 20 µg/$429; 1 mg/$1,973
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
14.0 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
15.1 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$281; 20 µg/$369
E. coli
His
Less than 0.1 EU/µg protein (determined by LAL method).
10 µg/$344
CHO Cells
Human Mutant IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$463; 10 µg/$358
CHO Cells
Mouse Mutant IgG2a Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$463; 10 µg/$358
E. coli
His
Less than 0.1 EU/µg protein (determined by LAL method).
50 µg/$621; 10 µg/$344
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
13.5 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$281; 20 µg/$369
E. coli
None
Biologically active
15.0 kDa
5 µg/$282; 100 µg/$1,030; 500 µg/$1,891
Human
None
15.4kDa
50 µg/$702; 10 µg/$323; 200 µg/$1,300; 100 µg/$1,098; 1 mg/$2,565; 500 µg/$2,063; 5 mg/$4,915; 2 mg/$2,757
Human
None
50 µg/$522; 10 µg/$294; 200 µg/$1,034; 100 µg/$832; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His-T7
16.3 kDa
10 µg/$295; 50 µg/$532; 100 µg/$850; 200 µg/$1,049; 1 mg/$2,215; 500 µg/$1,733; 5 mg/$3,711; 2 mg/$2,407
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product results
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