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IL6 / Interleukin 6

interleukin 6 (interferon, beta 2)

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Gene Name: interleukin 6 (interferon, beta 2)
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IL6, B-cell stimulatory factor 2, BSF-2, BSF2, CTL differentiation factor, Hybridoma growth factor, IFN-beta-2, Interleukin-6, Interleukin BSF-2, IFNB2, B-cell differentiation factor, CDF, HSF, IL-6
Target Sequences: NM_000600 NP_000591.1 P05231

Publications (17)

1
Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice. Chen C, Liu Y, Liu Y, Zheng P. The Journal of clinical investigation. 2010 120:4091-101. (Mouse) [PubMed:20972332] [PMC:PMC2964994] Related Antibodies: LS-C7955.
2
Fetal skin as a pro-inflammatory organ: Evidence from a primate model of chorioamnionitis. Boonkasidecha S, Kannan PS, Kallapur SG, Jobe AH, Kemp MW. PloS one. 2017 September;12:e0184938. (Human) [Full Text Article] [PubMed:28957335] [PMC:PMC5619751] Related Antibodies: LS-B7482.
3
Contribution of the Interleukin-6/STAT-3 Signaling Pathway to Chondrogenic Differentiation of Human Mesenchymal Stem Cells. Kondo M, Yamaoka K, Sakata K, Sonomoto K, Lin L, Nakano K, Tanaka Y. Arthritis & rheumatology (Hoboken, N.J.). 2015 May;67:1250-60. [Full Text Article] [PubMed:25604648]
4
Oleoylethanolamide treatment reduces neurobehavioral deficits and brain pathology in a mouse model of Gulf War Illness. Joshi U, Evans JE, Joseph R, Emmerich T, Saltiel N, Lungmus C, Oberlin S, Langlois H, Ojo J, Mouzon B, Paris D, Mullan M, Jin C, Klimas N, Sullivan K, Crawford F, Abdullah L. Scientific reports. 2018 August;8:12921. [Full Text Article] [PubMed:30150699] [PMC:PMC6110778]
5
The Morphopathogenetic Aspects of Intraabdominal Adhesions in Children under One Year of Age. Junga A, Pilmane M, Abola Z, Volrats O. Medicina (Kaunas). 2019 August;55:E556. [Full Text Article] [PubMed:31480453] [PMC:PMC6780280] Related Antibodies: LS-B1582.
6
IL-6 release from muscles during exercise is stimulated by lactate-dependent protease activity. Pernille Hojman, Camilla Brolin, Nynne Nørgaard-Christensen, Christine Dethlefsen, Britt Lauenborg, Cecilie Køllner Olsen, Mette Marie Åbom, Thomas Krag, Julie Gehl, Bente Klarlund Pedersen. American journal of physiology. Endocrinology and metabolism. 2019 May;316:E940-E947. [Full Text Article] [PubMed:30779630]
7
Mystery Solved: Why Smoke Extract Worsens Disease in Smokers with Crohn's Disease and Not Ulcerative Colitis? Gut MAP!. Dania AlQasrawi, Latifa S Abdelli, Saleh A Naser. Microorganisms. 2020 May;8:666. [Full Text Article] [PubMed:32370298] [PMC:PMC7284734]
8
Effects of arginase inhibition via jugular infusion of N?-hydroxy-nor-l-arginine on metabolic and immune indices in lactating dairy cows. L Y Ding, Y F Wang, Y Z Shen, G Zhou, X Zhang, M Z Wang, J J Loor, J Zhang. Journal of dairy science. 2019 Apr;102:3310-3320. [Full Text Article] [PubMed:30738683]
9
Inhibition of lncRNA H19/miR-370-3p pathway mitigates neuronal apoptosis in an in vitro model of spinal cord injury (SCI). Xin Li, Yan Qian, Kaihua Tang, Yang Li, Rui Tao, Chunyan Gong, Li Huang, Kaiwen Zou, Lindong Liu. Translational neuroscience. 2021 Mar;12:103-113. [Full Text Article] [PubMed:33708438] [PMC:PMC7925972] Related Antibodies: LS-C746886.
10
Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection. Raja Mohan Gopalakrishnan, Malika Aid, Noe B Mercado, Caitlin Davis, Shaily Malik, Emma Geiger, Valerie Varner, Rhianna Jones, Steven E Bosinger , Cesar Piedra-Mora, Amanda J Martinot , Dan H Barouch , R Keith Reeves , C Sabrina Tan. JCI insight. 2021 Oct;6:e152013. [Full Text Article] [PubMed:34676832] [PMC:PMC8564899] Related Antibodies: LS-A9692.
11
Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]
12
Cancer-Associated Exosomal CBFB Facilitates the Aggressive Phenotype, Evasion of Oxidative Stress, and Preferential Predisposition to Bone Prometastatic Factor of Breast Cancer Progression. Chia-Hung Hsu, Hon-Ping Ma, Jiann Ruey Ong, Ming-Shou Hsieh, Vijesh Kumar Yadav, Chi-Tai Yeh, Tsu-Yi Chao, Wei-Hwa Lee, Wen-Chien Huang, Kuang-Tai Kuo, Iat-Hang Fong, Chih-Cheng Lin, Chih-Ming Su. Disease Markers. 2022 July;2022:8446629. [Full Text Article] [PubMed:35903297] [PMC:PMC9325341]
13
Potentilla chinensis aqueous extract attenuates cyclophosphamide-induced hemorrhagic cystitis in rat model. Kajetan Juszczak, Jan Adamowicz, Lukasz Zapala, Tomasz Kluz, Przemyslaw Adamczyk, Artur Wdowiak, Iwona Bojar, Marcin Misiek, Magdalena Emilia Grzybowska, Klaudia Stangel-Wójcikiewicz, Ewa Poleszak, Marta Pokrywczynska, Tomasz Drewa, Andrzej Wróbel. Scientific reports. 2022 July;12:13076. [Full Text Article] [PubMed:35906474] [PMC:PMC9338276]
14
Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis. Jun Yang, Xiaoqian Li, Xuefeng Yang, Hongjiang Wei, Lipu Deng, Nian Fu. Experimental and therapeutic medicine. 2022 July;24:458. [Full Text Article] [PubMed:35747149] [PMC:PMC9204537]
15
Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]
16
Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions. Nancy S Younis, Maged E Mohamed, Nermin A El Semary. Marine drugs. 2022 January;20:56. [Full Text Article] [PubMed:35049911] [PMC:PMC8781738]
17
LncRNA H19 aggravates TNF-a-induced inflammatory injury via TAK1 pathway in MH7A cells. Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia. BioFactors (Oxford, England). 2020 September;46:813-820. [Full Text Article] [PubMed:32525617] Related Antibodies: LS-B7482.
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IL6 / Interleukin 6 Antibody - Anti-IL-6 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
IL6 / Interleukin 6 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
IL6 / Interleukin 6 Antibody - Anti-IL-6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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IL6 / Interleukin 6 Mouse anti-Human Monoclonal (6D9A1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
IL6 / Interleukin 6 Antibody - Anti-IL-6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroscience
IL6 / Interleukin 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µg/$485
IL6 / Interleukin 6 Antibody - Anti-IL-6 antibody IHC of rat spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Neuroscience
IL6 / Interleukin 6 Mouse anti-Rat Monoclonal (10E5) Antibody
Rat
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$595
IL6 / Interleukin 6 Antibody - Anti-IL-6 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
IL6 / Interleukin 6 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
IL6 / Interleukin 6 Antibody - Immunohistochemistry of paraffin-embedded human tonsil using IL6 antibody at dilution of 1:100 (40x lens).
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IL6 / Interleukin 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
IL6 / Interleukin 6 Antibody - 1:200 staining human breast carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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IL6 / Interleukin 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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IL6 / Interleukin 6 Rat anti-Mouse Monoclonal (Azide-free) Antibody
Mouse
ELISA, Flo, IHC, Neut, WB
Unconjugated, Azide-free
500 µg/$786
IL6 / Interleukin 6 Antibody - Immunohistochemistry with anti-IL-6 antibody showing nuclear positivity of islets of Langerhans (brown staining) and cytoplasmic staining in mouse pancreas at 10x and 20x (B & C). Staining was performed on Leica Bond system using the standard protocol. Formalin fixed/paraffin embedded tissue sections were subjected to antigen retrieval with E1 (Leica Microsystems) retrieval solution for 20 min and then incubated with rabbit anti-mouse IL-6 antibody at 1:50 dilution for 60 minutes. Biotinylated Anti-rabbit secondary antibody was used at 1:200 dilution to detect primary antibody. The reaction was developed using streptavidin-HRP conjugated compact polymer system and visualized with chromogen substrate, 3’3-diamino-benzidine substrate (DAB). The sections were then counterstained with hematoxylin to detect cell nuclei.
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IL6 / Interleukin 6 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, WB
Unconjugated
100 µg/$567
IL6 / Interleukin 6 Antibody - Anti-Human IL-6 Western Blot Reduced
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IL6 / Interleukin 6 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
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IL6 / Interleukin 6 Rabbit anti-Sheep Polyclonal (Serum) Antibody
Sheep
ELISA, WB
Unconjugated, Serum
0.1 ml/$570
IL6 / Interleukin 6 Antibody - IL-6 antibody (2C9) at 1:500000 + recombinant human IL-6.
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IL6 / Interleukin 6 Mouse anti-Human Monoclonal (OTI2C9) Antibody
Human
WB
Unconjugated
100 µl/$434
IL6 / Interleukin 6 Antibody - Western blot of recombinant IL6.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL6 / Interleukin 6 Guinea pig anti-Rabbit Polyclonal (aa27-241) Antibody
Rabbit
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
IL6 / Interleukin 6 Antibody - Western Blot; Sample: Recombinant IL6, Canine.
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IL6 / Interleukin 6 Rabbit anti-Dog Polyclonal (aa18-207) (APC) Antibody
Dog
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
IL6 / Interleukin 6 Antibody - IL6 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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IL6 / Interleukin 6 Rabbit anti-Human Polyclonal (aa27-55) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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IL6 / Interleukin 6 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
IL6 / Interleukin 6 ELISA Kit
Select
Development Kit
1000 Wells
Mouse
8 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Test/$540
IL6 / Interleukin 6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Hamster
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
IL6 / Interleukin 6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IL6 / Interleukin 6 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
3 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Select
CHO Cells
Human Mutant IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$358
IL6 / Interleukin 6 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$593
IL6 / Interleukin 6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$602
IL6 / Interleukin 6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$659
IL6 / Interleukin 6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$600
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).