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6737 Mowry Ave
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IL7
interleukin 7
IL7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.
| Gene Name: | interleukin 7 |
| Family/Subfamily: | IL-7/ IL-9 , not assigned-IL-7/ IL-9 |
| Synonyms: | IL7, IL-7, Interleukin-7, Interleukin 7 |
| Target Sequences: | NM_000880 NP_000871.1 P13232 |
Publications (1)
1
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Nicolas Severe, Nezihi Murat Karabacak, Karin Gustafsson, Ninib Baryawno, Gabriel Courties, Youmna Kfoury, Konstantinos D Kokkaliaris, Catherine Rhee, Dongjun Lee, Elizabeth W Scadden, Juan Esteban Garcia-Robledo, Thomas Brouse, Matthias Nahrendorf, Mehmet Toner, David T Scadden. Cell stem cell. 2019 October;25:570-583.e7. [Full Text Article]
[PubMed:31279774]
[PMC:PMC6778015]
Related Antibodies: LS-B14351.
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Products
Proteins
(35)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(31)
Target
IL7
(35)
Format
Animal-free
(1)
Publications
No
(35)
Tag
6His, C-terminus
(6)
6His-SUMO, N-terminus
(1)
8His, C-terminus
(1)
GST
(1)
His
(2)
His, C-Terminal
(2)
His, N-Terminal
(3)
His,C-terminus
(1)
His-T7
(1)
Human Mutant IgG1 Fc
(1)
Myc-DDK (Flag)
(2)
Species
Human
(23)
Mouse
(9)
Rat
(2)
Source
293T Cells
(1)
CHO Cells
(3)
E. coli
(17)
HEK 293 Cells
(5)
Human Cells
(2)
Insect Cells
(1)
Mammalian Cells
(4)
Wheat Germ Extract
(1)
Purification
Purified
(12)
Low Endotoxin Level
Low endotoxin level
(22)
Biologically Active
Biologically active
(17)
Animal-free
Animal-free
(1)
CHO Cells
Human Mutant IgG1 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$519
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.4kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
15.0 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.4 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
15.0 kDa
2 µg/$262; 10 µg/$335
E. coli
None
Biologically active
17.4 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
E. coli
None
Biologically active
14.9 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
E. coli
His
18.4 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
His-T7
21.2 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
E. coli
His
19.4 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Wheat Germ Extract
GST
42.46 kDa
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
20.19 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
20.19 kDa
100 µg/$494
E. coli
His, N-Terminal
21kDa
10 µg/$341; 50 µg/$812; 200 µg/$1,444; 100 µg/$1,226; 1 mg/$2,746; 500 µg/$2,241; 5 mg/$5,685; 2 mg/$3,032
HEK 293 Cells
His, N-Terminal
~17 kDa
200 µl/$283
HEK 293 Cells
His, N-Terminal
~17 kDa
100 µg/$298
HEK 293 Cells
8His, C-terminus
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 152 amino acid recombinant protein has a predicted molecular mass of approximately 18.8 kD. The DTT-reduced and non-reduced protein migrate at approximately 20- 30 kD by SDS-PAGE. The C-terminal contains an 8His-(TG8HGGQ)-tag.
10 µg/$352; 25 µg/$459; 100 µg/$1,065; 500 µg/$2,285
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
17.4 kDa
10 µg/$364; 1 mg/$4,545
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
18.4 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,095; 500 µg/$2,167
Insect Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 148 amino acid recombinant protein (with ADL-His9-SSGIEGR at N-terminus) has a predicted molecular mass of approximately 17 kD. The DTT-reduced and non-reduced protein migrates at approximately 20 kD by SDS-PAGE.
10 µg/$352; 25 µg/$459
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
17.5 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,932; 500 µg/$2,459
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
15.9 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,095; 500 µg/$1,987
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.4 kDa
10 µg/$317; 50 µg/$524
Viewing 1-25
of 35
product results
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