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IL7R / CD127

interleukin 7 receptor

IL7R / CD127 is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene.

Gene Name: interleukin 7 receptor
Family/Subfamily: Interleukin
Synonyms: IL7R, CD127, CD127 antigen, IL-7RA, IL-7 receptor subunit alpha, IL7RA, ILRA, Interleukin 7 receptor, CDW127, IL-7R subunit alpha, IL-7R-alpha
Target Sequences: NM_002185 NP_002176.2 P16871

Publications (1)

1
Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease. Yasunaga M, Manabe S, Matsumura Y. Scientific reports. 2017 September;7:10735. (Mouse) [Full Text Article] [PubMed:28878234] [PMC:PMC5587554] Related Antibodies: LS-B2830.

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Products
ELISA Kits (14)
Cell-Based Phosphorylation (1)
Custom (2)
Sandwich (11)
IL7R / CD127 (14)
Human (9)
Mouse (5)
Rat (1)
96-Well Microplate (5)
96-Well Strip Plate (9)
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Adherent Cell Cultures (1)
Cell Culture Supernatants (5)
Plasma (7)
Serum (11)
Tissue Homogenates (2)
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$699
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
312 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$624
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$699
IL7R / CD127 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$750
IL7R / CD127 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
10 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$897
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
IL7R / CD127 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$585
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$624
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.14 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$559
IL7R / CD127 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$968
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).