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Insulin

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Gene Name: Insulin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: INS, IRDN, IDDM2, Preproinsulin, ILPR, Insulin, MODY10, Proinsulin
Target Sequences: NM_000207 NP_000198.1 P01308

Publications (6)

1
Transgenic pigs with pancreas-specific expression of green fluorescent protein. Matsunari H, Kobayashi T, Watanabe M, Umeyama K, Nakano K, Kanai T, Matsuda T, Nagaya M, Hara M, Nakauchi H, Nagashima H. The Journal of reproduction and development. 2014 60:230-7. (IHC; Pig) [PubMed:24748398] [PMC:PMC4085388] Related Antibodies: LS-C24686.
2
Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation. Matsunari H, Watanabe M, Hasegawa K, Uchikura A, Nakano K, Umeyama K, Masaki H, Hamanaka S, Yamaguchi T, Nagaya M, Nishinakamura R, Nakauchi H, Nagashima H. Stem cell reports. 2020 January;14:21-33. [Full Text Article] [PubMed:31883918] [PMC:PMC6962638] Related Antibodies: LS-C24686.
3
Lipocalin-2 is an anorexigenic signal in primates. Peristera-Ioanna Petropoulou, Ioanna Mosialou, Steven Shikhel, Lihong Hao, Konstantinos Panitsas, Brygida Bisikirska, Na Luo, Fabiana Bahna, Jongho Kim, Patrick Carberry, Francesca Zanderigo, Norman Simpson, Mihran Bakalian, Suham Kassir, Lawrence Shapiro, Mark D Underwood, Christina M May, Kiran Kumar Soligapuram Sai, Matthew J Jorgensen, Cyrille B Confavreux, Sue Shapses, Blandine Laferrère, Akiva Mintz, J John Mann, Mishaela Rubin, Stavroula Kousteni. eLife. 2020 November;9: [Full Text Article] [PubMed:33231171] [PMC:PMC7685704]
4
Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice. Woosuk Kim , Hyun Jung Kwon , Hyo Young Jung, Soon-Sung Lim, Beom-Goo Kang, Yong-Bok Jo, Dong-Sool Yu, Soo Young Choi, In Koo Hwang, Dae Won Kim. Plants (Basel, Switzerland). 2021 Aug;10:1814. [Full Text Article] [PubMed:34579347] [PMC:PMC8468243] Related Antibodies: LS-B2526.
5
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification. Micucci C, Orciari S, Catalano A. PloS one. 9:e105550. [Full Text Article] [PubMed:25144301] [PMC:PMC4140809] Related Antibodies: LS-B2526.
6
Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg LA, Nakauchi H. Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar;110:4557-62. [Full Text Article] [PubMed:23431169] [PMC:PMC3607052] Related Antibodies: LS-C24686.
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Insulin ELISA Kit
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Sandwich
96-Well Microplate
Human
4.688 - 300 µIU/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Insulin ELISA Kit
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96-Well Microplate
Pig
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Insulin ELISA Kit
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96-Well Microplate
Chicken
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
Insulin ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$792
Insulin ELISA Kit
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Sandwich
96-Well Microplate
Monkey
10 - 160 µIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$848
Insulin ELISA Kit
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Sandwich
96-Well Microplate
Human
10 - 160 µIU/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$734
Insulin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Guinea pig
123.46 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$748
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Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Insulin ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Insulin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
123.46 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
Insulin ELISA Kit
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Sandwich
96-Well Microplate
Mouse, Bovine, Human, Rat, Pig
4.688 - 300 µIU/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
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96-Well Strip Plate
Human
61.73 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$764
Insulin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
123.5 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Insulin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Dog
0.78 - 50 mIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Insulin ELISA Kit
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Sandwich
96-Well Microplate
Rabbit
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
Insulin ELISA Kit
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Sandwich
96-Well Microplate
Rabbit
8 - 100 µIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$803
Insulin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Bovine
123.5 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.63 - 40 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
Insulin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
Insulin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rhesus monkey
123.46 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$826
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Sandwich
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
Insulin ELISA Kit
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Sandwich
96-Well Microplate
Pig
4.688 - 150 µIU/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
Insulin ELISA Kit
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Sandwich
96-Well Microplate
Bovine
4.688 - 150 µIU/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
Insulin ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$585
Insulin ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$585
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).