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JAK2

Janus kinase 2

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

Gene Name: Janus kinase 2
Family/Subfamily: Protein Kinase , TYK2/JAK
Synonyms: JAK2, JAK-2, JTK10, Tyrosine-protein kinase JAK2, THCYT3, Janus kinase 2
Target Sequences: NM_004972 NP_004963.1 O60674

☰ Filters
Antibodies (4)
Primary (4)
JAK2 (4)
Human (3)
Mouse (2)
Rat (2)
IHC (2)
WB (2)
ELISA (1)
Peptide-ELISA (1)
rabbit (3)
goat (1)
Product Group
Cytokine Release Syndrome (1)
IgG (3)
polyclonal pc (4)
Unconjugated (4)
No (4)
Select
JAK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$242; 60 µl/$278; 120 µl/$338; 200 µl/$440
JAK2 Antibody - JAK2 antibody flow cytometric analysis of paraformaldehyde fixed K562 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (0.4ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
Select
JAK2 Goat anti-Human Polyclonal Antibody
ELISA, Peptide-ELISA
Unconjugated
100 µg/$455
Select
JAK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
20 µl/$242; 60 µl/$278; 120 µl/$338; 200 µl/$440
Select
JAK2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$242; 60 µl/$278; 120 µl/$338; 200 µl/$440
Viewing 1-4 of 4 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).