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KITLG / SCF

KIT ligand

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Gene Name: KIT ligand
Synonyms: KITLG, C-Kit ligand, KIT ligand, Kitl, KL-1, SHEP7, SF, Steel factor, Stem cell factor, SCF, FPH2, Mast cell growth factor, MGF
Target Sequences: NM_000899 NP_000890.1 P21583

Publications (2)

1
The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour. Fukuzawa R, , Anaka MR, Morison IM, Reeve AE. PloS one. 2017 12:e0186333. (ICC, WB; Human) [Full Text Article] [PubMed:29040332] Related Antibodies: LS-B5002.
2
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Nicolas Severe, Nezihi Murat Karabacak, Karin Gustafsson, Ninib Baryawno, Gabriel Courties, Youmna Kfoury, Konstantinos D Kokkaliaris, Catherine Rhee, Dongjun Lee, Elizabeth W Scadden, Juan Esteban Garcia-Robledo, Thomas Brouse, Matthias Nahrendorf, Mehmet Toner, David T Scadden. Cell stem cell. 2019 October;25:570-583.e7. [Full Text Article] [PubMed:31279774] [PMC:PMC6778015]

☰ Filters
Products
Proteins (52)
Over-Expression Lysate (4)
Recombinant (48)
KITLG / SCF (52)
Animal-free (3)
No (52)
6His, C-terminus (5)
GST (2)
GST, N-terminus (1)
His (4)
His, N-Terminal (2)
His,C-terminus (3)
Human IgG1 Fc (1)
Human Mutant IgG1 Fc (1)
Mouse IgG1 Fc (1)
Mouse IgG2 Fc (2)
Mouse Mutant IgG2a Fc (1)
Myc-DDK (Flag) (4)
Human (25)
Mouse (14)
Pig (2)
Rat (9)
293F Cells (1)
293T Cells (2)
CHO Cells (7)
E. coli (27)
HEK 293 Cells (5)
Human Cells (1)
Mammalian Cells (4)
Wheat Germ Extract (2)
Yeast (3)
Purified (18)
Low endotoxin level (37)
Biologically active (21)
Animal-free (3)
Select
CHO Cells
Mouse IgG2 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$393
Select
CHO Cells
Mouse Mutant IgG2a Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$393
KITLG / SCF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
18.4 kDa
50 µg/$391; 10 µg/$294; 1 mg/$2,269; 500 µg/$1,540
KITLG / SCF Protein - TF-1 cell proliferation induced by mouse SCF
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 165 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of 18298.0 Da. The DTT-reduced protein migrates at approximately 18 kDa by SDS-PAGE. The non-reduced protein migrates at approximately 14 kDa by SDS-PAGE.
10 µg/$344; 25 µg/$459; 100 µg/$907; 500 µg/$1,540
KITLG / SCF Protein - TF-1 cell proliferation induced by human SCF.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 165 amino acid recombinant protein has a predicted molecular mass of approximately 18.6 kD. The DTT-reduced and non-reduced protein migrate at approximately 20 kD and 18 kD respectively by SDS-PAGE. The N-terminal amino acid is Met.
10 µg/$352; 25 µg/$497; 100 µg/$907; 500 µg/$1,559
KITLG / SCF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
30.9 kDa
100 µg/$494
KITLG / SCF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
27.87 kDa
100 µg/$494
KITLG / SCF Protein - 12.5% SDS-PAGE of human KITLG stained with Coomassie Blue
Select
Wheat Germ Extract
GST
54.3 kDa
10 µg/$479; 25 µg/$670
KITLG / SCF Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
KITLG / SCF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
30.9 kDa
20 µg/$150
KITLG / SCF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.87 kDa
20 µg/$150
KITLG / SCF Protein
Select
E. coli
GST
45.85 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.3 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.4 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.4 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$370
Select
HEK 293 Cells
His
20.4 kDa
10 µg/$347; 50 µg/$682; 100 µg/$1,018
Select
Yeast
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
18.4 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$296; 1 mg/$1,612
Select
CHO Cells
Mouse IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$389; 10 µg/$312
Select
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
10 µg/$319
Select
CHO Cells
Mouse IgG2 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$393
Select
CHO Cells
Human Mutant IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$393
KITLG / SCF Protein
Select
E. coli
None
Biologically active
18.4 kDa
10 µg/$388; 100 µg/$766; 500 µg/$1,501
Viewing 1-25 of 52 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).