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KLK2 / Kallikrein 2

kallikrein-related peptidase 2

KLK2 / Kallikrein 2 is a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants.

Gene Name: kallikrein-related peptidase 2
Family/Subfamily: Protease , Serine S1
Synonyms: KLK2, Glandular kallikrein 2, Glandular kallikrein-1, HGK-1, Kallikrein 2, prostatic, Kallikrein-2, Kallikrein-related peptidase 2, KLK2A2, Tissue kallikrein-2
Target Sequences: NM_005551 NP_005542.1 P20151

Publications (1)

1
Trp(250) -hK2 is defective in intracellular trafficking and activates the unfolded protein response. Eun Ju Choi, Sei Mee Yoon, Suman Lee, Jinu Lee. Genes to cells : devoted to molecular & cellular mechanisms. 2015 June;20:512-20. [Full Text Article] [PubMed:25847286] Related Antibodies: LS-C55038.

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Products
Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
KLK2 / Kallikrein 2 (10)
No (10)
6His, C-terminus (2)
6His, N-terminus (1)
GST (2)
His (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (9)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (2)
KLK2 / Kallikrein 2 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
KLK2 / Kallikrein 2 Protein - Purified recombinant protein KLK2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
28.5 kDa
20 µg/$1,107
KLK2 / Kallikrein 2 Protein - 12.5% SDS-PAGE of human KLK2 stained with Coomassie Blue
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Wheat Germ Extract
GST
51.1 kDa
10 µg/$479; 25 µg/$670
KLK2 / Kallikrein 2 Protein - Recombinant  Kallikrein 2 By SDS-PAGE
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E. coli
His-T7
30.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
KLK2 / Kallikrein 2 Protein - 12.5% SDS-PAGE of human KLK2 stained with Coomassie Blue
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Wheat Germ Extract
GST
54.34 kDa
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
28.5 kDa
20 µg/$150
KLK2 / Kallikrein 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
28.5 kDa
100 µg/$494
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27.9 kDa
10 µg/$344; 50 µg/$584
KLK2 / Kallikrein 2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27.9kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).