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KRAS
Kirsten rat sarcoma viral oncogene homolog
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. Mutations in this gene are associated with leukemia, lung, breast, bladder, pancreatic, and stomach cancer.
| Gene Name: | Kirsten rat sarcoma viral oncogene homolog |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , RAS oncogene |
| Synonyms: | KRAS, C-K-RAS, C-Ki-ras, C-Kirsten-ras protein, GTPase KRas, K-ras p21 protein, K-RAS2B, K-RAS2, KRAS2, NS, NS3, K-RAS4A, KRAS1, RASK2, Transforming protein p21, Oncogene KRAS2, K-Ras 2, K-RAS2A, K-RAS4B, KI-RAS, PR310 c-K-ras oncogene |
| Target Sequences: | NM_004985 NP_203524.1 P01116 |
Publications (2)
1
Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange. Guillard S, Kolasinska-Zwierz P, Debreczeni J, Breed J, Zhang J, Bery N, Marwood R, Tart J, Overman R, Stocki P, Mistry B, Phillips C, Rabbitts T, Jackson R, Minter R. Nature communications. 2017 July;8:16111. (Human)
[Full Text Article]
[PubMed:28706291]
[PMC:PMC5519984]
Related Antibodies: LS-C175665.
2
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling. Alexander N Kapustin, Paul Davey, David Longmire, Carl Matthews, Emily Linnane, Nitin Rustogi, Maria Stavrou, Paul W A Devine, Nicholas J Bond, Lyndsey Hanson, Silvia Sonzini, Alexey Revenko, A Robert MacLeod, Sarah Ross, Elisabetta Chiarparin, Sanyogitta Puri. Communications biology. 2021 Nov;4:1241. [Full Text Article]
[PubMed:34725463]
[PMC:PMC8560811]
Related Antibodies: LS-C175665.
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KRAS Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
KRAS Mouse anti-Human Monoclonal (2C1) Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$450
KRAS Mouse anti-Human Monoclonal (Carrier-free) (2C1) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
KRAS Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
KRAS Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Rat, Hamster, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
KRAS Mouse anti-Human Monoclonal (C-Terminus) (9.13) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$504
KRAS Rabbit anti-Human Polyclonal (aa146-174) Antibody
Mouse, Human
ELISA, Flo, IF, WB
Unconjugated
200 µl/$734
KRAS Rabbit anti-Human Polyclonal (aa146-174) (Biotin) Antibody
Mouse, Human
ELISA, Flo, IF, WB
Biotin Conjugated
200 µl/$952
KRAS Rabbit anti-Human Polyclonal (aa146-174) (PE) Antibody
Mouse, Rat, Human
ELISA, Flo, ICC, IF, WB
PE Conjugated
200 µl/$952
KRAS Rabbit anti-Human Polyclonal (aa146-174) (APC) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, WB
APC Conjugated
200 µl/$952
KRAS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
KRAS Rabbit anti-Human Polyclonal (aa2-168) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
KRAS Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
KRAS Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
50 µg/$294; 100 µg/$360
![KRAS Antibody - Immunofluorescence of monoclonal antibody to KRAS on HeLa cell. [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/kras-antibody-clone-3b10-2f2-ls-c197585/145500_4988692.jpg)
KRAS Mouse anti-Human Monoclonal (3B10-2F2) Antibody
Human
IF, WB
Unconjugated
100 µg/$423
Fast Shipping
KRAS Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
KRAS Mouse anti-Human Monoclonal (OTI5H6) Antibody
Human
WB
Unconjugated
100 µl/$434
KRAS Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$332
KRAS Rabbit anti-Human Polyclonal (aa2-168) Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
KRAS Rabbit anti-Human Polyclonal (aa1-189) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
KRAS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
KRAS Mouse anti-Human Monoclonal (OTI4F6) Antibody
Human
WB
Unconjugated
100 µl/$434
KRAS Mouse anti-Human Monoclonal (OTI4B3) Antibody
Human
WB
Unconjugated
100 µl/$434
KRAS Mouse anti-Human Monoclonal (OTI2F8) Antibody
Human
WB
Unconjugated
100 µl/$434
KRAS Rabbit anti-Human Polyclonal (aa1-189) Antibody
Pig, Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
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