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KRAS
Kirsten rat sarcoma viral oncogene homolog
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. Mutations in this gene are associated with leukemia, lung, breast, bladder, pancreatic, and stomach cancer.
| Gene Name: | Kirsten rat sarcoma viral oncogene homolog |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , RAS oncogene |
| Synonyms: | KRAS, C-K-RAS, C-Ki-ras, C-Kirsten-ras protein, GTPase KRas, K-ras p21 protein, K-RAS2B, K-RAS2, KRAS2, NS, NS3, K-RAS4A, KRAS1, RASK2, Transforming protein p21, Oncogene KRAS2, K-Ras 2, K-RAS2A, K-RAS4B, KI-RAS, PR310 c-K-ras oncogene |
| Target Sequences: | NM_004985 NP_203524.1 P01116 |
Publications (2)
1
Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange. Guillard S, Kolasinska-Zwierz P, Debreczeni J, Breed J, Zhang J, Bery N, Marwood R, Tart J, Overman R, Stocki P, Mistry B, Phillips C, Rabbitts T, Jackson R, Minter R. Nature communications. 2017 July;8:16111. (Human)
[Full Text Article]
[PubMed:28706291]
[PMC:PMC5519984]
Related Antibodies: LS-C175665.
2
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling. Alexander N Kapustin, Paul Davey, David Longmire, Carl Matthews, Emily Linnane, Nitin Rustogi, Maria Stavrou, Paul W A Devine, Nicholas J Bond, Lyndsey Hanson, Silvia Sonzini, Alexey Revenko, A Robert MacLeod, Sarah Ross, Elisabetta Chiarparin, Sanyogitta Puri. Communications biology. 2021 Nov;4:1241. [Full Text Article]
[PubMed:34725463]
[PMC:PMC8560811]
Related Antibodies: LS-C175665.
☰ Filters
Products
Proteins
(20)
Type
Over-Expression Lysate
(4)
Recombinant
(16)
Target
KRAS
(20)
Publications
No
(20)
Tag
6His, N-terminus
(6)
GST
(1)
GST, N-terminus
(1)
His
(4)
His-T7
(1)
Myc-DDK (Flag)
(6)
Myc-DDK (Flag), C-terminus
(1)
Species
Human
(18)
Source
293T Cells
(2)
E. coli
(11)
HEK 293 Cells
(5)
Wheat Germ Extract
(2)
Purification
Purified
(4)
Low Endotoxin Level
Low endotoxin level
(6)
Wheat Germ Extract
GST
46.42 kDa
10 µg/$479; 25 µg/$670
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.6 kDa
10 µg/$258; 50 µg/$352
HEK 293 Cells
Myc-DDK (Flag)
21.2 kDa
20 µg/$1,107
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
21.2 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
21.5 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
21.5 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
21.5 kDa
100 µg/$494
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.6 kDa
10 µg/$258; 50 µg/$352
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.6 kDa
10 µg/$258; 50 µg/$352
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.5 kDa
10 µg/$258; 50 µg/$352
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.5 kDa
10 µg/$258; 50 µg/$352
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.4 kDa
10 µg/$258; 50 µg/$352
HEK 293 Cells
Myc-DDK (Flag)
21.2 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag), C-terminus
21.2 kDa
20 µg/$1,107
E. coli
His-T7
25.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His
23.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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