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KRT8 / CK8 / Cytokeratin 8

keratin 8

KRT8 / CK8 / Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.

Gene Name: keratin 8
Family/Subfamily: Keratin , not assigned-Keratin
Synonyms: KRT8, CARD2, CK-8, CYK8, Cytokeratin-8, CK8, K2C8, K8, KO, Keratin-8, Type-II keratin Kb8, Cytokeratin 8, Keratin 8
Target Sequences: NM_002273 NP_002264.1 P05787

Publications (2)

1
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, Shiah YJ, Barsyte-Lovejoy D, Hofer S, Bader G, Lupien M, Arrowsmith C, Knapp S, De Carvalho D, Berman H, Boutros PC, Kislinger T, Khokha R. The Journal of cell biology. 2018 August;217:2951-2974. [Full Text Article] [PubMed:29921600] [PMC:PMC6080920] Related Antibodies: LS-B12422.
2
PDGFRa+<sup> stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland. Joshi PA, Waterhouse PD, Kasaian K, Fang H, Gulyaeva O, Sul HS, Boutros PC, Khokha R. Nature communications. 2019 April;10:1760. [Full Text Article] [PubMed:30988300] [PMC:PMC6465250] Related Antibodies: LS-B12422.

☰ Filters
Products
Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
KRT8 / CK8 / Cytokeratin 8 (11)
No (11)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
His-S (3)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (8)
Rat (2)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
KRT8 / CK8 / Cytokeratin 8 Protein
Select
E. coli
His-SUMO
66.5 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
KRT8 / CK8 / Cytokeratin 8 Protein - 12.5% SDS-PAGE of human KRT8 stained with Coomassie Blue
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Wheat Germ Extract
GST
80.1 kDa
10 µg/$479; 25 µg/$670
KRT8 / CK8 / Cytokeratin 8 Protein - Purified recombinant protein KRT8 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.5 kDa
20 µg/$1,107
KRT8 / CK8 / Cytokeratin 8 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
KRT8 / CK8 / Cytokeratin 8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
53.5 kDa
20 µg/$150
KRT8 / CK8 / Cytokeratin 8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
53.5 kDa
100 µg/$494
KRT8 / CK8 / Cytokeratin 8 Protein
Select
E. coli
6His, N-terminus
54 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
KRT8 / CK8 / Cytokeratin 8 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
E. coli
His-S
14.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,617
Select
E. coli
His-S
21.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
KRT8 / CK8 / Cytokeratin 8 Protein - Recombinant Keratin 8 By SDS-PAGE
Select
E. coli
His-S
40.9 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).