LAG3

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption. Hurst J, Hoffmann M, Pace M, Williams JP, Thornhill J, Hamlyn E, Meyerowitz J, Willberg C, Koelsch KK, Robinson N, Brown H, Fisher M, Kinloch S, Cooper DA, Schechter M, Tambussi G, Fidler S, Babiker A, Weber J, Kelleher AD, Phillips RE, Frater J. Nature communications. 2015 6:8495. (Flo; Human) [Full Text Article] [PubMed:26449164] [PMC:PMC4633715]

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection. Hoffmann M, Pantazis N, Martin GE, Hickling S, Hurst J, Meyerowitz J, Willberg CB, Robinson N, Brown H, Fisher M, Kinloch S, Babiker A, Weber J, Nwokolo N, Fox J, Fidler S, Phillips R, Frater J,; SPARTAC and CHERUB Investigators. PLoS pathogens. 2016 12:e1005661. (Flo; Human) [Full Text Article] [PubMed:27415828] [PMC:PMC4945085]

Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes. Norström MM, Rådestad E, Sundberg B, Mattsson J, Henningsohn L, Levitsky V, Uhlin M. Oncotarget. 2016 7:23581-93. (Flo, ELISA; Human) [Full Text Article] [PubMed:26993768] [PMC:PMC5029649]

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade. Chen PL, Roh W, Reuben A, Cooper ZA, Spencer CN, Prieto PA, Miller JP, Bassett RL, Gopalakrishnan V, Wani K, De Macedo MP, Austin-Breneman JL, Jiang H, Chang Q, Reddy SM, Chen WS, Tetzlaff MT, Broaddus RJ, Davies MA, Gershenwald JE, Haydu L, Lazar AJ, Patel SP, Hwu P, Hwu WJ, Diab A, Glitza IC, Woodman SE, Vence LM, Wistuba II, Amaria RN, Kwong LN, Prieto V, Davis RE, Ma W, Overwijk WW, Sharpe AH, Hu J, Futreal PA, Blando J, Sharma P, Allison JP, Chin L, Wargo JA. Cancer discovery. 2016 6:827-37. (IHC; Human) [Full Text Article] [PubMed:27301722] [PMC:PMC5082984]

The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects. Tian X, Zhang A, Qiu C, Wang W, Yang Y, Qiu C, Liu A, Zhu L, Yuan S, Hu H, Wang W, Wei Q, Zhang X, Xu J. Journal of immunology (Baltimore, Md. : 1950). 2015 194:3873-82. (IHC; Human) [Full Text Article] [PubMed:25780040]

Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma. Matias Autio, Suvi-Katri Leivonen, Oscar Brück, Satu Mustjoki, Judit Mészáros Jørgensen, Marja-Liisa Karjalainen-Lindsberg, Klaus Beiske, Harald Holte, Teijo Pellinen, Sirpa Leppä. Haematologica. 2020 February; [Full Text Article] [PubMed:32079690] [PMC:PMC7927991]

Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival. Sistiana Aiello, Federica Rocchetta, Lorena Longaretti, Silvia Faravelli, Marta Todeschini, Linda Cassis, Francesca Pezzuto, Susanna Tomasoni, Nadia Azzollini, Marilena Mister, Caterina Mele, Sara Conti, Matteo Breno, Giuseppe Remuzzi, Marina Noris, Ariela Benigni. Scientific reports. 2017 September;7:11518. [Full Text Article] [PubMed:28912528] [PMC:PMC5599553] Related Antibodies: LS-B14998.

Expansion of Gammadelta T Cells from Cord Blood: A Therapeutical Possibility. Sofia Berglund, Ahmed Gaballa, Piamsiri Sawaisorn, Berit Sundberg, Michael Uhlin. Stem cells international. 2018 May;2018:8529104. [Full Text Article] [PubMed:29707004] [PMC:PMC5863314]

The Cerebroventricular Environment Modifies CAR T Cells for Potent Activity against Both Central Nervous System and Systemic Lymphoma. Xiuli Wang, Christian Huynh, Ryan Urak, Lihong Weng, Miriam Walter, Laura Lim, Vibhuti Vyas, Wen-Chung Chang, Brenda Aguilar, Alfonso Brito, Aniee Sarkissian, N Achini Bandara, Lu Yang, Jinhui Wang, Xiwei Wu, Jianying Zhang, Saul J Priceman, Hong Qin, Larry W Kwak, Lihua E Budde, Sandra H Thomas, Mary C Clark, Leslie Popplewell, Tanya Siddiqi, Christine E Brown, Stephen J Forman. Cancer immunology research. 2020 October; [Full Text Article] [PubMed:33093217] [PMC:PMC8008993] Related Antibodies: LS-C130398.

Spatial Distribution and Prognostic Implications of Tumor-Infiltrating FoxP3- CD4+ T Cells in Biliary Tract Cancer. Hyung-Don Kim, Jwa Hoon Kim, Yeon-Mi Ryu, Danbee Kim, Sunmin Lee, Jaehoon Shin, Seung-Mo Hong, Ki-Hun Kim, Dong-Hwan Jung, Gi-Won Song, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Baek-Yeol Ryoo, Jae Ho Jeong, Kyu-Pyo Kim, Sang-Yeob Kim, Changhoon Yoo. Cancer research and treatment. 2020 August; [Full Text Article] [PubMed:32878426] [PMC:PMC7812013]

LAG3 is not expressed in human and murine neurons and does not modulate a-synucleinopathies. Marc Emmenegger, Elena De Cecco, Marian Hruska-Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa-Vergniory, Andrès Gonzalez-Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adria. EMBO molecular medicine. 2021 September;13:e14745. [Full Text Article] [PubMed:34309222] [PMC:PMC8422075] Related Antibodies: LS-B15026.

Presence of Tim3+ and PD-1+ CD8+ T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological features. Max Klapholz , Michael G Drage , Amitabh Srivastava, Ana C Anderson. The Journal of pathology. 2022 June;257:186-197. [Full Text Article] [PubMed:35119692]