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LDLR / LDL Receptor
low density lipoprotein receptor
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
| Gene Name: | low density lipoprotein receptor |
| Synonyms: | LDLR, FHC, LDL receptor, LDLCQ2 |
| Target Sequences: | NM_000527 NP_000518.1 P01130 |
Publications (5)
1
Peroxisome Proliferator-activated receptor activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. Duan Y, Chen Y, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J. The Journal of biological chemistry. 2012 287:23667-77. (ICC, IHC, WB; Mouse, Human)
[PubMed:22593575]
[PMC:PMC3390641]
2
PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction. Sun H, Krauss RM, Chang JT, Teng BB,. Journal of lipid research. 2018 59:207-223. (WB; Human)
[Full Text Article]
[PubMed:29180444]
3
Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer. Pires LA, Hegg R, Freitas FR, Tavares ER, Almeida CP, Baracat EC, Maranhão RC. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2012 45:557-64. (ICC; Mouse)
[PubMed:22570085]
Related Antibodies: LS-B1598.
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Antibodies
(93)
Type
Primary
(93)
Target
LDLR / LDL Receptor
(93)
Reactivity
Human
(68)
Mouse
(35)
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(15)
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(6)
Monkey
(4)
Pig
(1)
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(16)
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(1)
IHC-P
(13)
WB
(62)
Flo
(22)
ELISA
(28)
ICC
(9)
IF
(8)
IP
(7)
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(1)
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rabbit
(70)
mouse
(22)
chicken
(1)
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(2)
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(1)
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(23)
IgG1
(11)
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(1)
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(6)
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(1)
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monoclonal mc
(23)
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(70)
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004
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101
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(1)
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(5)
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(2)
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(2)
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(2)
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(3)
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(5)
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(9)
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(4)
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(3)
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(3)
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(2)
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(2)
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(2)
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(8)
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(6)
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(7)
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(1)
Preservative Free
(4)
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(45)
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aa263-509
(8)
aa335-588
(8)
aa497-742
(8)
aa391-419
(7)
Internal
(5)
aa451-500
(4)
aa1-790
(3)
Extracellular Domain
(2)
aa1-350
(1)
aa184-196
(1)
aa499-511
(1)
aa528-552
(1)
aa810-860
(1)
Publications
No
(91)
Yes
(2)
LDLR / LDL Receptor Rabbit anti-Mouse Polyclonal (aa499-511) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
1 Each/$485
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (Internal) (DY488) Antibody
Human, Monkey
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (aa1-350) Antibody
Mouse, Rat, Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$341
LDLR / LDL Receptor Mouse anti-Human Monoclonal (Extracellular Domain) (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$917
LDLR / LDL Receptor Mouse anti-Bovine Monoclonal (C7) Antibody
Bovine, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$386
LDLR / LDL Receptor Mouse anti-Bovine Monoclonal (Biotin) (C7) Antibody
Bovine, Rat, Pig, Human
ICC, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
LDLR / LDL Receptor Mouse anti-Bovine Monoclonal (DY550) (C7) Antibody
Bovine, Human
ICC, IHC, IHC-P, IP, WB
DY550 Conjugated
0.1 ml/$416
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (aa451-500) Antibody
Human
WB
Unconjugated
100 µl/$424
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (aa451-500) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (aa451-500) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (aa184-196) Antibody
Rat, Human
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
50 µl/$461; 250 µl/$958
LDLR / LDL Receptor Mouse anti-Bovine Monoclonal Antibody
Bovine, Human
Flo, IF, WB
Unconjugated
50 µg/$898
LDLR / LDL Receptor Rabbit anti-Mouse Monoclonal (aa1-790) (Preservative Free) (004) Antibody
Mouse
ICC, IF
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
LDLR / LDL Receptor Rabbit anti-Mouse Monoclonal (aa1-790) (Preservative Free) (101) Antibody
Mouse
ICC, IF
Unconjugated, Preservative Free
100 µl/$412
LDLR / LDL Receptor Mouse anti-Human Monoclonal (OTI8D12) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (Extracellular Domain) (Biotin) Antibody
Human
Flo, WB
Biotin Conjugated
250 µl/$1,044
LDLR / LDL Receptor Rabbit anti-Mouse Polyclonal (aa1-790) Antibody
Mouse
ELISA, Flo, ICC, IF
Unconjugated
100 µl/$412
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (APC) Antibody
Human
Flo
APC Conjugated
25 Tests/$263; 100 Tests/$323
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (PE) Antibody
Human
Flo
PE Conjugated
25 Tests/$263; 100 Tests/$278
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (aa497-742) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
LDLR / LDL Receptor Chicken anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
LDLR / LDL Receptor Rabbit anti-Rat Polyclonal (aa335-588) (HRP) Antibody
Mouse, Rat
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
LDLR / LDL Receptor Rabbit anti-Human Polyclonal (aa810-860) Antibody
Human
IHC-P, IP
Unconjugated
50 µl/$460
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