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LDLR / LDL Receptor

low density lipoprotein receptor

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Gene Name: low density lipoprotein receptor
Synonyms: LDLR, FHC, LDL receptor, LDLCQ2
Target Sequences: NM_000527 NP_000518.1 P01130

Publications (5)

1
Peroxisome Proliferator-activated receptor activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. Duan Y, Chen Y, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J. The Journal of biological chemistry. 2012 287:23667-77. (ICC, IHC, WB; Mouse, Human) [PubMed:22593575] [PMC:PMC3390641]
2
PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction. Sun H, Krauss RM, Chang JT, Teng BB,. Journal of lipid research. 2018 59:207-223. (WB; Human) [Full Text Article] [PubMed:29180444]
3
Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer. Pires LA, Hegg R, Freitas FR, Tavares ER, Almeida CP, Baracat EC, Maranhão RC. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2012 45:557-64. (ICC; Mouse) [PubMed:22570085] Related Antibodies: LS-B1598.
4
Non-Native Conformational Isomers of the Catalytic Domain of PCSK9 Induce an Immune Response, Reduce Lipids and Increase LDL Receptor Levels. Jiang C, Nischal H, Sun H, Li L, Cao Y, Wei P, Chang JY, Teng BB. International journal of molecular sciences. 2018 February;19:pii: E640. (Human) [Full Text Article] [PubMed:29495280] [PMC:PMC5855862]
5
Integrated proteomics and metabolomics analysis reveals differential lipid metabolism in human umbilical vein endothelial cells under high and low shear stress. Gabriela Venturini, Pamella Araujo Malagrino, Kallyandra Padilha, Leonardo Yuji Tanaka, Francisco Rafael Laurindo, Rafael Dariolli, Valdemir Melechco Carvalho, Karina Helena Morais Cardozo, Jose Eduardo Krieger, Alexandre da Costa Pereira. American journal of physiology. Cell physiology. 2019 August;317:C326-C338. [Full Text Article] [PubMed:31067084] Related Antibodies: LS-B10039.
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ELISA Kits (26)
Custom (5)
Sandwich (20)
Sandwich CLIA (1)
LDLR / LDL Receptor (26)
Human (10)
Mouse (6)
Rat (4)
Monkey (1)
Pig (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (3)
96-Well Strip Plate (22)
No (26)
Cell Culture Supernatants (5)
Cell Lysates (2)
Plasma (17)
Serum (15)
Tissue Homogenates (7)
Urine (4)
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$968
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Microplate
Human
8.192 - 800 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
LDLR / LDL Receptor ELISA Kit
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Custom
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$968
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
LDLR / LDL Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
LDLR / LDL Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
LDLR / LDL Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$585
LDLR / LDL Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
LDLR / LDL Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
LDLR / LDL Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
LDLR / LDL Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Tissue Homogenates
1 Plate/$579
LDLR / LDL Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
LDLR / LDL Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
LDLR / LDL Receptor ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$624
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Tissue Homogenates
1 Plate/$579
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$624
LDLR / LDL Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$699
LDLR / LDL Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$699
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
LDLR / LDL Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).