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Leptin
Leptin is a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
| Gene Name: | Leptin |
| Synonyms: | LEP, Leptin, LEPD, Obese protein, Obese, mouse, homolog of, Obesity factor, OBS, OB |
| Target Sequences: | NM_000230 NP_000221.1 P41159 |
Publications (6)
1
Leptin as a potential target for estrogen receptor-positive breast cancer. Yom CK, Lee KM, Han W, Kim SW, Kim HS, Moon BI, Jeong KY, Im SA, Noh DY. Journal of breast cancer. 2013 16:138-45. (WB; Human)
[Full Text Article]
[PubMed:23843844]
[PMC:PMC3706857]
Related Antibodies: LS-C25172.
2
Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Jones HN, Olbrych SK, Smith KL, Cnota JF, Habli M, Ramos-Gonzales O, Owens KJ, Hinton AC, Polzin WJ, Muglia LJ, Hinton RB. Placenta. 2015 36:1078-86. (WB; Mouse)
[Full Text Article]
[PubMed:26278057]
Related Antibodies: LS-B1459.
3
Delta-like protein 1 in the pituitary-adipose axis in the adult male mouse. Bello AR, Puertas-Avendaño RA, González-Gómez MJ, González-Gómez M, Laborda J, Damas C, Ruiz-Hidalgo M, Diaz C. Journal of neuroendocrinology. 2017 August;29: [Full Text Article]
[PubMed:28718206]
[PMC:PMC6084355]
☰ Filters
Products
Proteins
(35)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(30)
Target
Leptin
(35)
Publications
No
(35)
Tag
8His, N-terminus
(1)
GST
(1)
His
(4)
His, N-Terminal
(3)
His, N-terminus
(1)
His,N-terminus
(1)
His-GST, N-terminus
(1)
His-S
(1)
His-S, N-terminus
(1)
His-T7
(2)
Myc-DDK (Flag)
(3)
Species
Bovine
(2)
Chicken
(1)
Goldfish
(1)
Horse
(1)
Human
(21)
Mouse
(5)
Rat
(3)
Source
293T Cells
(1)
E. coli
(27)
HEK 293 Cells
(4)
Wheat Germ Extract
(1)
Yeast
(1)
Purification
Purified
(12)
Low Endotoxin Level
Low endotoxin level
(15)
Biologically Active
Biologically active
(10)
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.0 kDa
200 µg/$268; 1 mg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.2 kDa
200 µg/$268; 1 mg/$349
E. coli
His, N-terminus
18.4 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
E. coli
His-S
21.7 kDa
10 µg/$246; 50 µg/$299; 100 µg/$352; 200 µg/$442; 1 mg/$1,242; 500 µg/$882; 5 mg/$2,097; 2 mg/$1,391
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.2 kDa
200 µg/$268; 1 mg/$349
E. coli
None
Biologically active
16.0 kDa
200 µg/$275
E. coli
His-T7
17.7 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,441
E. coli
His-T7
20.0 kDa
10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113
E. coli
His
17.3 kDa
10 µg/$223; 50 µg/$243; 200 µg/$275; 100 µg/$262; 1 mg/$482; 500 µg/$339; 5 mg/$1,042; 2 mg/$562
E. coli
His
19.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
16.3 kDa (SDS-PAGE)
5 mg/$432; 200 µg/$253; 1 mg/$286
Wheat Germ Extract
GST
41.8 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
16 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
18.64 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
18.64 kDa
20 µg/$150
HEK 293 Cells
His, N-Terminal
~16 kDa
100 µg/$298
HEK 293 Cells
His, N-Terminal
~16 kDa
200 µl/$283
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
16.0 kDa
1 mg/$355; 200 µg/$278; 5 mg/$670
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
16.1 kDa
10 µg/$225; 50 µg/$253
E. coli
None
Less than 0.1 ng/µg protein.
16.2 kDa
1000 µg/$427; 5000 µg/$836; 200 µg/$741
E. coli
None
Biologically active
16.0 kDa
200 µg/$279; 1 mg/$365
E. coli
None
Biologically active
16.2 kDa
200 µg/$279; 1 mg/$365
E. coli
His-S, N-terminus
22.6kDa
10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
E. coli
His-GST, N-terminus
46kDa
10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
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