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LGR6

leucine-rich repeat containing G protein-coupled receptor 6

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

Gene Name: leucine-rich repeat containing G protein-coupled receptor 6
Family/Subfamily: GPCR , Orphan-A
Synonyms: LGR6, VTS20631
Target Sequences: AB049405 CAD13082.1 Q9HBX8

Publications (1)

1
Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions. Nan Chiang, Stephania Libreros, Paul C Norris, Xavier de la Rosa, Charles N Serhan. The Journal of clinical investigation. 2019 Dec;129:5294-5311. [Full Text Article] [PubMed:31657786] [PMC:PMC6877300] Related Antibodies: LS-A442.

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Products
Antibodies (18)
Primary (18)
LGR6 (18)
Human (18)
Mouse (2)
Rat (2)
IHC (7)
IHC-P (3)
WB (12)
ELISA (4)
IF (6)
Peptide-ELISA (2)
rabbit (16)
mouse (2)
Product Group
GPCR Database Antibodies (2)
IHCPlus (1)
PathPlus Neuro (1)
IgG (12)
IgG1 (2)
monoclonal mc (2)
polyclonal pc (16)
OTI2A3 (2)
Biotin Conjugated (1)
Carrier-free (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (15)
Internal (2)
440-520 aa, Internal (1)
N-terminal extracellular domain (1)
aa25-250 (1)
aa471-520 (1)
No (17)
Yes (1)
LGR6 Antibody - Brain, Amygdala
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Neuroscience
LGR6 Rabbit anti-Human Polyclonal (N-terminal extracellular domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
LGR6 Antibody - Anti-LGR6 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
LGR6 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
LGR6 Antibody - Immunofluorescence analysis of LOVO cells, using LGR6 Antibody. The picture on the right is blocked with the synthesized peptide.
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LGR6 Rabbit anti-Human Polyclonal (aa471-520) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
LGR6 Antibody - Immunohistochemistry image of paraffin-embedded human appendix tissue at a dilution of 1:100
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LGR6 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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LGR6 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
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LGR6 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
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LGR6 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
LGR6 Antibody - Western blot of LGR6 antibody
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LGR6 Rabbit anti-Human Polyclonal (440-520 aa, Internal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LGR6 Antibody - Anti-LGR6 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR6.
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LGR6 Mouse anti-Human Monoclonal (OTI2A3) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
LGR6 Antibody - Anti-LGR6 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR6.
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LGR6 Mouse anti-Human Monoclonal (aa25-250) (Carrier-free) (OTI2A3) Antibody
Human
IF, WB
Unconjugated, Carrier-free
100 µg/$511
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LGR6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$468
LGR6 Antibody - Western blot analysis of extracts of various cell lines.
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LGR6 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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LGR6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
LGR6 Antibody - Peptide - + Immunofluorescence analysis of LOVO cells, using LGR6 antibody.
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LGR6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
LGR6 Antibody - Staining HuvEc cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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LGR6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
LGR6 Antibody - Immunohistochemistry of paraffin-embedded Rat brain using LGR6 Polyclonal Antibody at dilution of 1:100 (40x lens).
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LGR6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
LGR6 Antibody - Western blot analysis of LGR6 expression in L929 (A); mouse brain (B); rat kidney (C) whole cell lysates.
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LGR6 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
LGR6 Antibody - Western blot analysis of extracts of rat testis, using LGR6 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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LGR6 Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).