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LHCGR / LHR / LH Receptor

luteinizing hormone/choriogonadotropin receptor

LHCGR is a Glycoprotein Hormone Receptor for both luteinizing hormone and choriogonadotropin. It is expressed in the reproductive organs of both males and females. In males, the luteinizing hormone/choriogonadotropin receptor is involved in the development and function of Leydig cells. Mutations in this gonadotropin receptor can result in disorders of male secondary sexual character development, such as familial male precocious puperty and male pseudohermaphroditism, or lead to adenomas of the testis. In females, inactivating mutations of LHCGR cause hypergonadotrophic hypogonadism with primary amenorrhea or oligomenorrhea, cystic ovaries, and infertility. LHCGR has many alternatively spliced isoforms that affect where this gene is expressed.

Gene Name: luteinizing hormone/choriogonadotropin receptor
Family/Subfamily: GPCR , Glycoprotein hormone
Synonyms: LHCGR, HCG receptor, HHG, LCGR, LH/CGR, LHR, LH receptor, LHRHR, Lutropin receptor, LGR2, LH/CG-R, LSH-R, ULG5, Luteinizing hormone receptor
Target Sequences: NM_000233 NP_000224.2 P22888

Publications (6)

1
Effect of stallion age on the expression of LH and FSH receptors and aromatase P450 in equine male reproductive tissues. Herrera-Luna CV, Scarlet D, Walter I, Aurich C. Reproduction, fertility, and development. 2016 28:2016-2026. (WB, IHC-P; Human) [Full Text Article] [PubMed:26143654] Related Antibodies: LS-C312710.
2
Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article] [PubMed:29966501] [PMC:PMC6033701] Related Antibodies: LS-C312710.
3
Reduced Gonadotrophin Receptor Expression Is Associated with a More Aggressive Ovarian Cancer Phenotype. Janelle Cheung, Noor A Lokman, Riya D Abraham, Anne M Macpherson, Eunice Lee, Frank Grutzner, Nicolae Ghinea, Martin K Oehler , Carmela Ricciardelli. International journal of molecular sciences. 2020 Dec;22:71. [Full Text Article] [PubMed:33374698] [PMC:PMC7793521] Related Antibodies: LS-C334599.
4
Transition to the ovulatory season in mares: An investigation of antral follicle receptor gene expression in vivo. Ghassan M A Ishak, Gabriel A Dutra, Gustavo D A Gastal, Melba O Gastal, Jean M Feugang, Eduardo L Gastal. Molecular reproduction and development. 2019 December;86:1832-1845. [Full Text Article] [PubMed:31571308] Related Antibodies: LS-C312710.
5
Exposure to N-monoacetyl-p-phenylenediamine impaired ovarian function in mice. Liliang Yu, Jingwei Zhai, Yingxiong Wang, Yanqing Geng, Xuemei Chen, Yixian Wen, Hongyu Tang, Rao Yu, Yue Zhang, Xueqing Liu. Journal of applied toxicology : JAT. 2021 December;41:2031-2041. [Full Text Article] [PubMed:34014586] Related Antibodies: LS-C312710.
6
A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCGß Expression and Cell Differentiation. Cheong ML, Wang LJ, Chuang PY, Chang CW, Lee YS, Lo HF, Tsai MS, Chen H. Molecular and cellular biology. 2016 36:197-209. (WB; Human) [Full Text Article] [PubMed:26503785] [PMC:PMC4702603] Related Antibodies: LS-C312710.
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Proteins (6)
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LHCGR / LHR / LH Receptor (6)
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6His, N-terminus (1)
DDK,C-terminus (1)
His (3)
His-SUMO (1)
Human (3)
Rat (3)
E. coli (2)
Mammalian Cells (2)
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LHCGR / LHR / LH Receptor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Mammalian Cells
6His, N-terminus
100 µg/$1,116; 20 µg/$461; 1 mg/$3,921
LHCGR / LHR / LH Receptor Protein
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E. coli
His
41.67 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
LHCGR / LHR / LH Receptor Protein
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E. coli
His-SUMO
53.13 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
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Yeast
His
39.57 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
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Yeast
His
39.15 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
LHCGR / LHR / LH Receptor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
DDK,C-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).