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LIF

leukemia inhibitory factor

Leukaemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes.

Gene Name: leukemia inhibitory factor
Synonyms: LIF, DIA, Emfilermin, HILDA, Melanoma-derived LPL inhibitor, MLPLI, Leukemia inhibitory factor, CDF, D factor, Human interleukin in DA cells
Target Sequences: NM_002309 NP_002300.1 P15018

Publications (1)

1
Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer. Man-Tzu Wang, Nicole Fer, Jacqueline Galeas, Eric A Collisson, Sung Eun Kim, Jeremy Sharib, Frank McCormick. Nature communications. 2019 July;10:3055. [Full Text Article] [PubMed:31296870] [PMC:PMC6624260] Related Antibodies: LS-B7078.

☰ Filters
Products
Proteins (40)
Over-Expression Cell Culture Supernatant (2)
Over-Expression Lysate (4)
Recombinant (34)
LIF (40)
Animal-free (1)
No (40)
6His, N-terminus (5)
Fc, C-terminus (1)
GST (1)
His (2)
His, N-Terminal (3)
His,C-terminus (2)
His-T7 (2)
Myc-DDK (Flag) (3)
Bovine (1)
Dog (1)
Human (23)
Mouse (13)
Rat (1)
293T Cells (1)
CHO Cells (1)
E. coli (24)
HEK 293 Cells (12)
Wheat Germ Extract (1)
Yeast (1)
Purified (9)
Low endotoxin level (20)
Biologically active (13)
Animal-free (1)
Select
HEK 293 Cells
6His, N-terminus
22 kDa
100 µg/$298
LIF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
19.7 kDa
50 µg/$516; 10 µg/$313; 1 mg/$3,095; 500 µg/$2,064
LIF Protein - Recombinant Bovine leukemia inhibitory factor detected using Chicken anti Bovine leukemia inhibitory factor as the capture reagent and Chicken anti Bovine leukemia inhibitory factor:Biotin as the detection reagent followed by Streptavidin:HRP.
Select
Yeast
None
19.8 kDa
5 µg/$390
Select
E. coli
None
Biologically active
Less than 0.1 EU/µg protein (determined by LAL method).
This 180 amino acid protein has a predicted molecular mass of approximately 20 kD. The protein migrates at approximately 20 kD in DTT-reducing conditions and approximately 18 kD in non-reducing condition by SDS-PAGE. The predicted N-terminal amino acid is
10 µg/$302; 25 µg/$355; 100 µg/$820; 500 µg/$1,663
LIF Protein - Human leukemia inhibitory factor (LIF) induces proliferation of TF-1 cells in a dose dependent manner.
Select
E. coli
None
Biologically active
Less than 0.1 EU/µg protein (determined by LAL method).
The 180 amino acid recombinant protein has a predicted molecular mass of approximately 20 kD. The protein migrates at about 20 kD in DTT-reducing conditions and about 18 kD in non-reducing condition by SDS-PAGE. The N-terminal amino acid is Ser.
10 µg/$302; 25 µg/$355; 100 µg/$820; 500 µg/$1,663
Select
E. coli
None
Biologically active
19.9 kDa
5 µg/$268; 25 µg/$349
Select
E. coli
None
Biologically active
19.9 kDa
5 µg/$282; 25 µg/$370
LIF Protein
Select
E. coli
None
Less than 0.1 EU/µg protein (determined by LAL method).
19.8 kDa
20 µg/$677
Select
HEK 293 Cells
6His, N-terminus
20 kDa
200 µl/$283
Select
HEK 293 Cells
6His, N-terminus
20 kDa
100 µg/$298
Select
HEK 293 Cells
6His, N-terminus
22 kDa
200 µl/$283
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
19.9 kDa (SDS-PAGE)
50 µg/$521; 10 µg/$296; 1 mg/$2,783
LIF Protein - Purified recombinant protein LIF was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
19.7 kDa
20 µg/$1,107
LIF Protein
Select
E. coli
None
Biologically active
19.7 kDa
5 µg/$282; 100 µg/$893; 500 µg/$1,668
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
19.7 kDa
5 µg/$268; 25 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
19.7 kDa
5 µg/$281; 25 µg/$369
LIF Protein - Active Leukemia Inhibitory Factor (LIF) by WB
Select
E. coli
His, N-Terminal
26kDa
10 µg/$285; 50 µg/$470; 200 µg/$937; 100 µg/$750; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
LIF Protein - Recombinant Leukemia Inhibitory Factor By SDS-PAGE
Select
E. coli
His-T7
25.5 kDa
10 µg/$272; 50 µg/$385; 100 µg/$615; 200 µg/$770; 1 mg/$1,828; 500 µg/$1,388; 5 mg/$2,788; 2 mg/$2,010
LIF Protein - Recombinant Leukemia Inhibitory Factor By SDS-PAGE
Select
E. coli
His-T7
23.8 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
LIF Protein - Recombinant Leukemia Inhibitory Factor By SDS-PAGE
Select
E. coli
His
21.3 kDa
10 µg/$277; 50 µg/$415; 100 µg/$662; 200 µg/$830; 1 mg/$1,916; 500 µg/$1,465; 5 mg/$2,899; 2 mg/$2,101
LIF Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
22 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
LIF Protein
Select
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
LIF Protein - 12.5% SDS-PAGE of human LIF stained with Coomassie Blue
Select
Wheat Germ Extract
GST
48.4 kDa
2 µg/$439
LIF Protein - Figure: Human Leukemia Inhibitory Factor (LIF) (rec.) (AG-40B-0093) maintains pluripotency of mouse ES cells. Method: Mouse ES oct4 GFP cells were cultured for 3 days in the presence of the indicated concentrations of LIF and followed by flow cytometry analysis of the GFP expression (indicating the expression of Oct4, thus of pluripotency).
Select
E. coli
None
Less than 0.05 EU/µg protein (determined by LAL method).
~46kDa (SDS-PAGE)
10 µg/$309
LIF Protein - The ED(50) was determined by the dose-dependent differentiation of M1 myeloid leukemic cells was found to be in the range of 0.01 ng/mL.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~20 kDa
10 µg/$291; 100 µg/$597; 1 mg/$1,587
Viewing 1-25 of 40 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).