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LILRB2 / ILT4

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

LILRB2 / ILT4 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: LILRB2, CD85D, CD85d antigen, Ig-like transcript 4, LIR-2, MIR-10, MIR10, ILT-4, ILT4, LIR2
Target Sequences: NM_005874 NP_005865.3 Q8N423

Publications (1)

1
Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma. Kevin T Lynch, Samuel J Young, Max O Meneveau, Nolan A Wages, Victor H Engelhard, Craig L Slingluff Jr, Ileana S Mauldin. Journal for immunotherapy of cancer. 2021 June;9: [Full Text Article] [PubMed:34103353] [PMC:PMC8190052] Related Antibodies: LS-B9762.

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LILRB2 / ILT4 (5)
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LILRB2 / ILT4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
LILRB2 / ILT4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
LILRB2 / ILT4 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
LILRB2 / ILT4 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
LILRB2 / ILT4 ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$823
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).