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6737 Mowry Ave
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United States

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LMNA / Lamin A+C

lamin A/C

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Gene Name: lamin A/C
Synonyms: LMNA, 70 kDa lamin, CDCD1, CMD1A, EMD2, FPLD, IDC, FPL, FPLD2, Lamin A/C, Lamin, LFP, LMNC, LMN1, LMNL1, HGPS, Prelamin-A/C, PRO1, Lamin A, Lamin A/C-like 1, LGMD1B, CDDC, CMT2B1, LDP1
Target Sequences: NM_005572 NP_005563.1 P02545

Publications (5)

1
Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Zhang Y, Wang Z, Magnuson NS. Molecular cancer research : MCR. 2007 5:909-22. [PubMed:17855660] Related Antibodies: LS-B2005.
2
Meiotic chromosome pairing and bouquet formation during Eimeria tenella sporulation. del Cacho E, Pags M, Gallego M, Barbero JL, Monteagudo L, Snchez-Acedo C. International journal for parasitology. 2010 40:453-62. (WB, IHC-Fr; Eimeria tenella) [PubMed:19837073] Related Antibodies: LS-C25073.
3
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. Takezaki S, Yamada M, Kato M, Park MJ, Maruyama K, Yamazaki Y, Chida N, Ohara O, Kobayashi I, Ariga T. Journal of immunology (Baltimore, Md. : 1950). 2012 189:1521-6. [PubMed:22730530] Related Antibodies: LS-B2005.
4
The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis. Lanzicher T, Martinelli V, Puzzi L, Del Favero G, Codan B, Long CS, Mestroni L, Taylor MR, Sbaizero O. Scientific reports. 2015 5:13388. (ICC; Human) [Full Text Article] [PubMed:26323789] [PMC:PMC4555041]
5
AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Lanzicher T, Martinelli V, Long CS, Del Favero G, Puzzi L, Borelli M, Mestroni L, Taylor MR, Sbaizero O. Nucleus (Austin, Tex.). 2015 6:394-407. (ICC; Human) [Full Text Article] [PubMed:26309016] [PMC:PMC4915516]
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LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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PathPlus™ LMNA / Lamin A+C Antibody (C-Terminus) LS-B2005
Neuroscience
(5.0) Rating
(2) Publication(s)
LMNA / Lamin A+C Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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IHC-plus™ LMNA / Lamin A+C Antibody (aa249-266) LS-B119
(4.0) Rating
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (aa249-266) Antibody
Rabbit, Mouse, Dog, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
LMNA / Lamin A+C Antibody - IHC of paraffin-embedded H441 Xenograft using Lamin A/C antibody at 1:100 dilution.
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LMNA / Lamin A+C Antibody (aa59-572) LS-C186225
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (aa59-572) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
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LMNA / Lamin A+C Antibody LS-C25073
(4.0) Rating
(1) Publication(s)
LMNA / Lamin A+C Mouse anti-Xenopus Monoclonal Antibody
Xenopus, Rat, Mouse, Bovine, Human
IF, IHC, IHC-Fr, WB
Unconjugated
50 µg/$891
LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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PathPlus™ LMNA / Lamin A+C Antibody (aa464-572, clone JOL2) LS-B2973
Neuroscience
(5.0) Rating
LMNA / Lamin A+C Mouse anti-Human Monoclonal (aa464-572) (JOL2) Antibody
Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
0.05 ml/$485
LMNA / Lamin A+C Antibody - Immunohistochemical analysis of Lamin A/C staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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LMNA / Lamin A+C Antibody (Internal) LS-C352469
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Rat, Pig, Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
LMNA / Lamin A+C Antibody - Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
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LMNA / Lamin A+C Antibody (aa572-646, clone JOL4) LS-C82328
LMNA / Lamin A+C Mouse anti-Human Monoclonal (aa572-646) (JOL4) Antibody
Mouse, Human
IF, IHC, IHC-Fr, IP, WB
Unconjugated
1 ml/$429
LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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PathPlus™ LMNA / Lamin A+C Antibody (clone 133A2) LS-B7178
Neuroscience
(5.0) Rating
LMNA / Lamin A+C Mouse anti-Human Monoclonal (133A2) Antibody
Mouse, Dog, Bovine, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$440
LMNA / Lamin A+C Antibody - HeLa cells staining with LMNA / Lamin A/C antibody (red), and counterstained with 6E2 monoclonal antibody to Lysosomal Associated Membrane Protein 1 (Lamp1, green) and DNA (blue). The LMNA / Lamin A/C antibody antibody reveals strong nuclear lamina staining, while MCA-6E2 antibody reveals strong cytoplasmic punctate staining of lysosomes and early endosomes. Since both DNA (blue) and Lamin A/C (red) are associated with the nuclear compartment, this region appears crimson in this image.
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LMNA / Lamin A+C Antibody LS-C204529
LMNA / Lamin A+C Chicken anti-Human Polyclonal Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$376
LMNA / Lamin A+C Antibody - This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LMNA / Lamin A+C Antibody (C-Terminus, Sepharose) LS-C171858
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (C-Terminus) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
LMNA / Lamin A+C Antibody - Immunofluorescent staining on frozen tissue section of human colon showing nuclear lamina staining in epithelial and connective tissue cells
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LMNA / Lamin A+C Antibody (clone 131C3) LS-C146766
LMNA / Lamin A+C Mouse anti-Human Monoclonal (131C3) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Hamster, Human
Flo, ICC, IHC, IHC-Fr, WB
Unconjugated
0.1 mg/$424
LMNA / Lamin A+C Antibody - Immunohistochemical analysis of Lamin A/C staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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LMNA / Lamin A+C Antibody (Internal) LS-C352468
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
LMNA / Lamin A+C Antibody - Immunohistochemical analysis of Lamin A/C (pS392) staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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LMNA / Lamin A+C Antibody (phospho-Ser392) LS-C354018
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (pSer392) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$315
LMNA / Lamin A+C Antibody - 1:100 staining mouse spleen tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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LMNA / Lamin A+C Antibody (phospho-Ser392) LS-C800917
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (pSer392) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
LMNA / Lamin A+C Antibody - 1:50 dilution staining Lamin A/C in human breast carcinoma by IHC using paraffin-embedded tissue.
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LMNA / Lamin A+C Antibody LS-C801542
LMNA / Lamin A+C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
LMNA / Lamin A+C Antibody - Anti-LMNA / Lamin A/C antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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IHC-plus™ LMNA / Lamin A+C Antibody (aa212-261) LS-B7729
(4.0) Rating
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (aa212-261) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
LMNA / Lamin A+C Antibody - Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.
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LMNA / Lamin A+C Antibody (aa481-646) LS-C357473
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (aa481-646) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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LMNA / Lamin A+C Antibody (aa598-611) LS-C25076
LMNA / Lamin A+C Mouse anti-Human Monoclonal (aa598-611) Antibody
Mouse, Dog, Bovine, Rat, Human
Flo, ICC, IHC, IHC-Fr, WB
Unconjugated
100 µg/$658
LMNA / Lamin A+C Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Lamin A/B (Ab-392) antibody.
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LMNA / Lamin A+C Antibody (p392) LS-C821858
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (p392) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
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LMNA / Lamin A+C Antibody LS-C757223
LMNA / Lamin A+C Goat anti-Human Polyclonal Antibody
Human
WB
Unconjugated
300 µg/$422
LMNA / Lamin A+C Antibody - Western blot of Lamin A/C expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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LMNA / Lamin A+C Antibody LS-C417355
LMNA / Lamin A+C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
LMNA / Lamin A+C Antibody - Western blot of Lamin A/C phosphorylation expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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LMNA / Lamin A+C Antibody (phospho-Ser392) LS-C416438
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (pSer392) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
LMNA / Lamin A+C Antibody - Detection of Human Lamin-A /C by Immunohistochemistry. Samples: FFPE sections of human colon carcinoma. Antibody: Affinity purified rabbit anti-Lamin-A/C used at a dilution of 1:200 (1 ug/ml) (left) and 1:1000 (0.2 ug/ml) (right). Detection: DAB.
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LMNA / Lamin A+C Antibody (aa1-50) LS-C286166
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
ICC, IF, IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
LMNA / Lamin A+C Antibody - IHC-P: Lamin A/C antibody testing of human lung cancer tissue
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LMNA / Lamin A+C Antibody (aa455-469) LS-C388836
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (aa455-469) Antibody
Rabbit, Mouse, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$575
LMNA / Lamin A+C Antibody - Detection of Human Lamin-A by Immunohistochemistry. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-Lamin-A used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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LMNA / Lamin A+C Antibody (aa400-450) LS-C290110
LMNA / Lamin A+C Rabbit anti-Human Polyclonal (aa400-450) Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
10 µl/$295; 100 µl/$514
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