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LOX / Lysyl Oxidase
lysyl oxidase
Lysyl Oxidase / LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | lysyl oxidase |
| Synonyms: | LOX, Lysyl oxidase, Protein-lysine 6-oxidase |
| Target Sequences: | NM_002317 NP_002308.2 P28300 |
Publications (16)
1
Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B. Jeay S, Pianetti S, Kagan HM, Sonenshein GE. Molecular and cellular biology. 2003 23:2251-63.
[PubMed:12640111]
[PMC:PMC150722]
2
The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. Palamakumbura AH, Jeay S, Guo Y, Pischon N, Sommer P, Sonenshein GE, Trackman PC. The Journal of biological chemistry. 2004 279:40593-600.
[PubMed:15277520]
3
Tumor suppressive effect of lysyl oxidase proenzyme. Contente S, Yeh TJ, Friedman RM. Biochimica et biophysica acta. 2009 1793:1272-8.
[PubMed:19410608]
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LOX / Lysyl Oxidase
(126)
Reactivity
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(87)
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(32)
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(29)
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(50)
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(1)
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(28)
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(91)
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(23)
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(25)
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(61)
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(31)
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(1)
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(21)
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(24)
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(7)
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monoclonal mc
(31)
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(62)
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(5)
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(2)
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(4)
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(4)
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(6)
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(6)
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(47)
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(14)
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(8)
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(8)
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(5)
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(5)
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(5)
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(1)
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(1)
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(1)
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(125)
Yes
(1)
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(1)
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(1)
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(14)
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(9)
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(1)
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(1)
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(1)
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(1)
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(10)
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(5)
LOX / Lysyl Oxidase Rabbit anti-Human Polyclonal (aa118-168) Antibody
Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
LOX / Lysyl Oxidase Rabbit anti-Human Polyclonal (aa118-168) (DY650) Antibody
Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
LOX / Lysyl Oxidase Mouse anti-Human Monoclonal (OTI9G2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
LOX / Lysyl Oxidase Mouse anti-Human Monoclonal (OTI5C4) Antibody
Dog, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
LOX / Lysyl Oxidase Rabbit anti-Human Polyclonal (aa305-320) Antibody
Rabbit, Mouse, Human, Monkey
IHC, IHC-Fr, IP, WB
Unconjugated
100 µl/$386
LOX / Lysyl Oxidase Rabbit anti-Mouse Polyclonal (aa78-115) Antibody
Mouse, Rat, Pig, Primate, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
LOX / Lysyl Oxidase Rabbit anti-Human Polyclonal (aa300-400) Antibody
Mouse, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
0.05 ml/$386
LOX / Lysyl Oxidase Rabbit anti-Human Polyclonal (aa213-417) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
LOX / Lysyl Oxidase Mouse anti-Human Monoclonal (OTI8G5) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
LOX / Lysyl Oxidase Mouse anti-Human Monoclonal (9A11) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Baculovirus
MBP, N-terminus + 6His, C-terminus
100 µg/$810; 20 µg/$387; 1 mg/$1,678
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
Sandwich
96-Well Microplate
Mouse
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Microplate
Human
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
LOX / Lysyl Oxidase Mouse anti-Human Monoclonal (OTI6B7) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
LOX / Lysyl Oxidase Mouse anti-Human Monoclonal (OTI10D11) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
Sandwich
96-Well Strip Plate
Pig
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
LOX / Lysyl Oxidase Mouse anti-Human Monoclonal (aa234-260) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
LOX / Lysyl Oxidase Mouse anti-Human Monoclonal (OTI4E3) Antibody
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
E. coli
6His, N-terminus
32.5 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
E. coli
His-GST, N-terminus
55.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
LOX / Lysyl Oxidase Rabbit anti-Rat Polyclonal Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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product results
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