Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Location


Corporate Headquarters

Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

Telephone Numbers



Customer Service: (800) 227-6666 / (650) 697-3600


Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

LRP2 / Megalin

low density lipoprotein receptor-related protein 2

LRP2 / Megalin, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Gene Name: low density lipoprotein receptor-related protein 2
Synonyms: LRP2, DBS, Glycoprotein 330, gp330, Megalin, LRP-2, Calcium sensor protein
Target Sequences: NM_004525 NP_004516.2 P98164

Publications (1)

1
Genetic Analyses in Dent Disease and Characterization of CLCN5 Mutations in Kidney Biopsies. Lisa Gianesello, Monica Ceol, Loris Bertoldi, Liliana Terrin, Giovanna Priante, Luisa Murer, Licia Peruzzi, Mario Giordano, Fabio Paglialonga, Vincenzo Cantaluppi, Claudio Musetti, Giorgio Valle, Dorella Del Prete, Franca Anglani, Dent Disease Italian Network. International journal of molecular sciences. 2020 Jan;21:516. [Full Text Article] [PubMed:31947599] [PMC:PMC7014080]

☰ Filters
Antibodies (33)
ELISA Kits (8)
Proteins (2)
Primary (33)
Recombinant (2)
Sandwich (8)
LRP2 / Megalin (43)
Human (35)
Mouse (7)
Rat (8)
IHC (13)
IHC-P (9)
WB (14)
ELISA (12)
Peptide-ELISA (1)
rabbit (33)
Product Group
IHCPlus (2)
PathPlus Cancer (1)
IgG (20)
polyclonal pc (33)
96-Well Microplate (1)
96-Well Strip Plate (7)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Preservative Free (2)
Unconjugated (15)
C-Terminus (8)
aa4035-4184 (8)
N-Terminus (1)
No (43)
Cell Culture Supernatants (2)
Plasma (8)
Serum (8)
Tissue Homogenates (5)
6His, N-terminus (2)
Human (2)
E. coli (1)
Yeast (1)
LRP2 / Megalin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$468
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$379
LRP2 / Megalin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$730
LRP2 / Megalin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
LRP2 / Megalin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
LRP2 / Megalin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
LRP2 / Megalin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
LRP2 / Megalin Protein
Select
Yeast
6His, N-terminus
24.2 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
LRP2 / Megalin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (aa4035-4184) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
LRP2 / Megalin Protein - Recombinant Low Density Lipoprotein Receptor Related Protein 2 By SDS-PAGE
Select
E. coli
6His, N-terminus
21.1 kDa
10 µg/$252; 50 µg/$315; 100 µg/$417; 200 µg/$522; 1 mg/$1,404; 500 µg/$1,034; 5 mg/$2,303; 2 mg/$1,565
LRP2 / Megalin Antibody - Western blot analysis of Lrp2/Megalin using COLO205 whole cells lysates
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
LRP2 / Megalin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
LRP2 / Megalin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
LRP2 / Megalin Antibody - Immunohistochemistry of paraffin-embedded Human esophagus cancer using LRP2 Polyclonal Antibody at dilution of 1:40.
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
LRP2 / Megalin Antibody - Western blot of LRP2 / Megalin antibody.
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (aa4035-4184) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
LRP2 / Megalin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
LRP2 / Megalin Antibody - Immunohistochemistry image at a dilution of 1:600 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
LRP2 / Megalin Antibody - Immunohistochemistry image at a dilution of 1:500 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system.
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
200 µl/$952
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
ELISA, IHC
FITC Conjugated
200 µl/$952
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (C-Terminus) (PE) Antibody
Human
ELISA, IHC
PE Conjugated
200 µl/$952
Select
LRP2 / Megalin Rabbit anti-Human Polyclonal (C-Terminus) (APC) Antibody
Human
ELISA, IHC
APC Conjugated
200 µl/$952
Viewing 1-25 of 43 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).