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MBP / Myelin Basic Protein

myelin basic protein

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Gene Name: myelin basic protein
Synonyms: MBP, Myelin A1 protein, Myelin basic protein
Target Sequences: NM_002385 NP_002376.1 P02686

Publications (5)

1
Cranial nerve involvement in patients with MOG antibody-associated disease. Cobo-Calvo A, Ayrignac X, Kerschen P, Horellou P, Cotton F, Labauge P, Vukusic S, Deiva K, Serguera C, Marignier R. Neurology(R) neuroimmunology & neuroinflammation. 2019 February;6:e543. [Full Text Article] [PubMed:30800725] [PMC:PMC6384017] Related Antibodies: LS-B2231.
2
Staurosporine, an inhibitor of hormonally up-regulated neu-associated kinase. Zambrano JN, Williams CJ, Williams CB, Hedgepeth L, Burger P, Dilday T, Eblen ST, Armeson K, Hill EG, Yeh ES. Oncotarget. 2018 November;9:35962-35973. [Full Text Article] [PubMed:30542510] [PMC:PMC6267597]
3
pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. David Kremer, Joel Gruchot, Vivien Weyers, Lisa Oldemeier, Peter Göttle, Luke Healy, Jeong Ho Jang, Yu Kang T Xu, Christina Volsko, Ranjan Dutta, Bruce D Trapp, Hervé Perron, Hans-Peter Hartung, Patrick Küry. Proceedings of the National Academy of Sciences of the United States of America. 2019 Jul;116:15216-15225. [Full Text Article] [PubMed:31213545] [PMC:PMC6660731]
4
Wharton's Jelly Mesenchymal Stem Cells Protect the Immature Brain in Rats and Modulate Cell Fate. Martin Mueller , Byron Oppliger , Marianne Joerger-Messerli , Ursula Reinhart , Eytan Barnea, Michael Paidas, Boris W Kramer , Daniel V Surbek , Andreina Schoeberlein. The Breast : official journal of the European Society of Mastology. 2017 Feb;26:239-248. [Full Text Article] [PubMed:27842457] Related Antibodies: LS-B2231.
5
Immunoreactivity of myelin-associated oligodendrocytic basic protein in Lewy bodies. Tomoya Kon, Kunikazu Tanji, Fumiaki Mori, Akari Kimura, Akiyoshi Kakita, Koichi Wakabayashi. Neuropathology : official journal of the Japanese Society of Neuropathology. 2019 August;39:279-285. [Full Text Article] [PubMed:31183926] Related Antibodies: LS-B2231.
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MBP / Myelin Basic Protein (39)
Human (12)
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MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
MBP / Myelin Basic Protein ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
MBP / Myelin Basic Protein ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MBP / Myelin Basic Protein ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MBP / Myelin Basic Protein ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
MBP / Myelin Basic Protein ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$723
MBP / Myelin Basic Protein ELISA Kit
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Sandwich
96-Well Microplate
Pig
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MBP / Myelin Basic Protein ELISA Kit
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Competitive EIA
96-Well Strip Plate
Chicken
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
MBP / Myelin Basic Protein ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
MBP / Myelin Basic Protein ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
MBP / Myelin Basic Protein ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MBP / Myelin Basic Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).