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MBP / Myelin Basic Protein

myelin basic protein

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Gene Name: myelin basic protein
Synonyms: MBP, Myelin A1 protein, Myelin basic protein
Target Sequences: NM_002385 NP_002376.1 P02686

Publications (5)

1
Cranial nerve involvement in patients with MOG antibody-associated disease. Cobo-Calvo A, Ayrignac X, Kerschen P, Horellou P, Cotton F, Labauge P, Vukusic S, Deiva K, Serguera C, Marignier R. Neurology(R) neuroimmunology & neuroinflammation. 2019 February;6:e543. [Full Text Article] [PubMed:30800725] [PMC:PMC6384017] Related Antibodies: LS-B2231.
2
Staurosporine, an inhibitor of hormonally up-regulated neu-associated kinase. Zambrano JN, Williams CJ, Williams CB, Hedgepeth L, Burger P, Dilday T, Eblen ST, Armeson K, Hill EG, Yeh ES. Oncotarget. 2018 November;9:35962-35973. [Full Text Article] [PubMed:30542510] [PMC:PMC6267597]
3
pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. David Kremer, Joel Gruchot, Vivien Weyers, Lisa Oldemeier, Peter Göttle, Luke Healy, Jeong Ho Jang, Yu Kang T Xu, Christina Volsko, Ranjan Dutta, Bruce D Trapp, Hervé Perron, Hans-Peter Hartung, Patrick Küry. Proceedings of the National Academy of Sciences of the United States of America. 2019 Jul;116:15216-15225. [Full Text Article] [PubMed:31213545] [PMC:PMC6660731]
4
Wharton's Jelly Mesenchymal Stem Cells Protect the Immature Brain in Rats and Modulate Cell Fate. Martin Mueller , Byron Oppliger , Marianne Joerger-Messerli , Ursula Reinhart , Eytan Barnea, Michael Paidas, Boris W Kramer , Daniel V Surbek , Andreina Schoeberlein. The Breast : official journal of the European Society of Mastology. 2017 Feb;26:239-248. [Full Text Article] [PubMed:27842457] Related Antibodies: LS-B2231.
5
Immunoreactivity of myelin-associated oligodendrocytic basic protein in Lewy bodies. Tomoya Kon, Kunikazu Tanji, Fumiaki Mori, Akari Kimura, Akiyoshi Kakita, Koichi Wakabayashi. Neuropathology : official journal of the Japanese Society of Neuropathology. 2019 August;39:279-285. [Full Text Article] [PubMed:31183926] Related Antibodies: LS-B2231.
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Proteins (26)
Over-Expression Lysate (12)
Recombinant (14)
MBP / Myelin Basic Protein (26)
No (26)
6His-SUMO, N-terminus (1)
GST (1)
His (1)
His, N-Terminal (3)
His-GST (2)
His-GST, N-terminus (1)
Myc-DDK (Flag) (17)
Cow (1)
Crab-eating macaque (1)
Human (16)
Mouse (1)
Rabbit (1)
293F Cells (1)
293T Cells (6)
E. coli (7)
HEK 293 Cells (11)
Wheat Germ Extract (1)
Purified (3)
MBP / Myelin Basic Protein Protein - Recombinant Myelin Basic Protein By SDS-PAGE
Select
E. coli
His, N-Terminal
26.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
MBP / Myelin Basic Protein Protein - Eukaryotic Myelin Basic Protein (MBP) by SDS-PAGE
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293F Cells
His, N-Terminal
46kDa
10 µg/$307; 50 µg/$602; 200 µg/$1,156; 100 µg/$962; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562
MBP / Myelin Basic Protein Protein - Recombinant Myelin Basic Protein By SDS-PAGE
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E. coli
His-GST
38 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
MBP / Myelin Basic Protein Protein
Select
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
17.2 kDa
100 µg/$494
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.9 kDa
100 µg/$494
MBP / Myelin Basic Protein Protein - Recombinant Myelin Basic Protein By SDS-PAGE
Select
E. coli
His-GST
38.1 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
MBP / Myelin Basic Protein Protein - 12.5% SDS-PAGE of human MBP stained with Coomassie Blue
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Wheat Germ Extract
GST
43.7 kDa
10 µg/$479; 25 µg/$670
MBP / Myelin Basic Protein Protein - Purified recombinant protein MBP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
18.4 kDa
20 µg/$1,107
MBP / Myelin Basic Protein Protein - Purified recombinant protein MBP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
32.9 kDa
20 µg/$1,107
MBP / Myelin Basic Protein Protein - Purified recombinant protein MBP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
21.3 kDa
20 µg/$1,107
MBP / Myelin Basic Protein Protein - Purified recombinant protein MBP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
17.2 kDa
20 µg/$1,107
MBP / Myelin Basic Protein Protein - Purified recombinant protein MBP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
21.3 kDa
20 µg/$1,107
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
21.3 kDa
100 µg/$494
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
18.4 kDa
100 µg/$494
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
21.3 kDa
100 µg/$494
Select
293T Cells
Myc-DDK (Flag)
21.3 kDa
20 µg/$150
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
21.3 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
18.4 kDa
20 µg/$150
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
17.2 kDa
20 µg/$150
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
21.3 kDa
20 µg/$150
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
32.9 kDa
20 µg/$150
MBP / Myelin Basic Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
21.3 kDa
100 µg/$494
MBP / Myelin Basic Protein Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
MBP / Myelin Basic Protein Protein - Recombinant Myelin Basic Protein (MBP) by SDS-PAGE
Select
E. coli
His, N-Terminal
22kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,838
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).