MLH1

mutL homolog 1

Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

MLH1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human MLH1 Protein (Recombinant GST) (Full Length) - LS-G29342

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

108.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MLH1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66327

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.4 kDa

Price:

20 µg/$1,107

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Human MLH1 Protein (Recombinant GST, N-terminus) (aa647-756) - LS-G59247

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MLH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77483

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.4 kDa

Price:

20 µg/$150

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MLH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98981

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.4 kDa

Price:

100 µg/$494

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