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MME / CD10

membrane metallo-endopeptidase

MME / CD10 is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Gene Name: membrane metallo-endopeptidase
Family/Subfamily: Protease , Metallopeptidase M13
Synonyms: MME, Atriopeptidase, CALLA, CD10, EPN, Membrane metallo-endopeptidase, NEP, Neprilysin, Neutral endopeptidase, Neutral endopeptidase 24.11, CD10 antigen, Enkephalinase, Neprylisin, SFE, Skin fibroblast elastase
Target Sequences: NM_000902 NP_000893.2 P08473

Publications (1)

1
A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. Denny MF, Yalavarthi S, Zhao W, Thacker SG, Anderson M, Sandy AR, McCune WJ, Kaplan MJ. Journal of immunology (Baltimore, Md. : 1950). 2010 184:3284-97. [PubMed:20164424] [PMC:PMC2929645] Related Antibodies: LS-C41007.

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Products
ELISA Kits (17)
Custom (3)
Sandwich (14)
MME / CD10 (17)
Human (8)
Mouse (5)
Rat (3)
Pig (1)
96-Well Microplate (4)
96-Well Strip Plate (13)
No (17)
Cell Culture Supernatants (5)
Plasma (14)
Serum (14)
Tissue Homogenates (4)
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
MME / CD10 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
MME / CD10 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
93.7 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$632
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
93.7 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
MME / CD10 ELISA Kit
Select
Custom
96-Well Microplate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$635
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.41 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
MME / CD10 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
MME / CD10 ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$968
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).