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MMP2

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Gene Name:	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Family/Subfamily:	Protease , Metallopeptidase M10A
Synonyms:	MMP2, 72 kd type iv collagenase, 72 kDa gelatinase, 72 kd gelatinase, 72 kDa type IV collagenase, CLG4A, CLG4, GelA, Gelatinase A, Matrix metalloproteinase-2, MMP-2, MONA, Neutrophil gelatinase, TBE-1, Tbe-1 metalloprotease, Matrix metalloproteinase-II, MMP-II
Target Sequences:	NM_004530 NP_004521.1 P08253

Publications (17)

The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-alpha. Alcorn JM, Fierer J, Chojkier M. Hepatology (Baltimore, Md.). 1992 15:122-9. (WB; Human) [PubMed:1727788]

Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression. Muir D. Clinical & experimental metastasis. 1995 13:303-14. [PubMed:7606893]

Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan. Zuo J, Ferguson TA, Hernandez YJ, Stetler-Stevenson WG, Muir D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 18:5203-11. (Chicken) [PubMed:9651203]

MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve. Ferguson TA, Muir D. Molecular and cellular neurosciences. 2000 16:157-67. (WB; Mouse) [PubMed:10924258]

Computed tomographic images reflect the biologic behavior of small lung adenocarcinoma: they correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix, and K-ras mutation. Dong B, Sato M, Sakurada A, Sagawa M, Endo C, Wu S, Yamanaka S, Horii A, Kondo T. The Journal of thoracic and cardiovascular surgery. 2005 130:733-9. (IHC-P; Human) [PubMed:16153921]

Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Wang XM, Yu DM, McCaughan GW, Gorrell MD. Hepatology (Baltimore, Md.). 2005 42:935-45. [PubMed:16175601]

Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium. Rork TH, Hadzimichalis NM, Kappil MA, Merrill GF. Journal of molecular and cellular cardiology. 2006 40:553-61. [PubMed:16530785]

Vascular endothelial growth factor expression in the basal subtype of breast carcinoma. Ribeiro-Silva A, Ribeiro do Vale F, Zucoloto S. American journal of clinical pathology. 2006 125:512-8. (IHC-P; Human) [PubMed:16627261]

Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. Locke NR, Royce SG, Wainewright JS, Samuel CS, Tang ML. American journal of respiratory cell and molecular biology. 2007 36:625-32. (IHC-P; Mouse) [PubMed:17237192]

Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2. Horak CE, Lee JH, Elkahloun AG, Boissan M, Dumont S, Maga TK, Arnaud-Dabernat S, Palmieri D, Stetler-Stevenson WG, Lacombe ML, Meltzer PS, Steeg PS. Cancer research. 2007 67:7238-46. (WB; Human) [PubMed:17671192]

Microscopic mammalian retinal pigment epithelium lesions induce widespread proliferation with differences in magnitude between center and periphery. von Leithner PL, Ciurtin C, Jeffery G. Molecular vision. 2010 16:570-81. (ICC, IHC; Rat) [PubMed:20360994] [PMC:PMC2847682]

B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:10649-54. (IHC) [PubMed:20498063] [PMC:PMC2890809]

Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats. Raaf L, Noll C, Cherifi, Samuel JL, Delcayre C, Delabar JM, Benazzoug Y, Janel N. Molecular and cellular biochemistry. 2011 347:63-70. (WB; Mouse) [PubMed:20938722]

Matrix metalloproteinase-2 and -9 activities in the human lens epithelial cells and serum of steroid induced posterior subcapsular cataracts. Alapure BV, Praveen MR, Gajjar DU, Vasavada AR, Parmar TJ, Arora AI. Molecular vision. 2012 18:64-73. [PubMed:22259225] [PMC:PMC3260085]

A Chinese herbal formula "Gan-Lu-Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways. Chien YC, Sheu MJ, Wu CH, Lin WH, Chen YY, Cheng PL, Cheng HC. BMC complementary and alternative medicine. 2012 12:137. (WB; Rat) [PubMed:22920190] [PMC:PMC3475136]

Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth. Sung SY, Wu IH, Chuang PH, Petros JA, Wu HC, Zeng HJ, Huang WC, Chung LW, Hsieh CL. Oncotarget. 2014 5:9911-29. (IHC; Human) [Full Text Article] [PubMed:25294816] [PMC:PMC4259447]

Acupuncture prevents the postpartum reduction in matrix metalloproteinase type-2 immunoexpression, tissue concentration and enzyme activity in bovine caruncles. Katrina Hiebel, Lauren Gentle, Alfred Menino, Michelle Kutzler. Reproduction in domestic animals = Zuchthygiene. 2019 July;54:1010-1017. [Full Text Article] [PubMed:31066470]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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